Immunological modification of adriamycin cardiotoxicity

N. Savaraj, L. M. Allen, C. Sutton, M. Troner

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Adriamycin-specific antibody has been shown to increase the survival of mice receiving an acute cardiotoxic dose of adriamycin. The concentrations of adriamycin in heart tissue were reduced and those in tumor elevated for more than 2 days in animals that received the antibody. The adriamycin-specific antibody prevented and reversed adriamycin inhibition of cardiac microsomal Na-K ATPase.

Original languageEnglish (US)
Pages (from-to)549-559
Number of pages11
JournalResearch communications in chemical pathology and pharmacology
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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