Immunological identification of a high molecular weight protein as a candidate for the product of the Duchenne muscular dystrophy gene

L. Kao, J. Krstenansky, J. Mendell, K. W. Rammohan, E. Gruenstein

Research output: Contribution to journalArticle

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Abstract

An oligopeptide was synthesized based on translation of the nucleotide sequence of the putative exon region of clone pERT87-25 from the gene for Duchenne muscular dystrophy. Immunization of rabbits with this oligopeptide induced the formation of antibodies directed against a protein present in human, rat, and rabbit skeletal muscle. This protein, which is missing in the skeletal muscle of two patients with Duchenne muscular dystrophy, has a molecular mass of ~320-420 kDa and is clearly different from the putative Duchenne muscular dystrophy-related protein nebulin. The data suggest that this 320- to 420-kDa protein is produced by the Duchenne muscular dystrophy gene.

Original languageEnglish (US)
Pages (from-to)4491-4495
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number12
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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