TY - JOUR
T1 - Immunological findings in neurological diseases associated with antibodies to HTLV‐I
T2 - Activated lymphocytes in tropical spastic paraparesis
AU - Jacobson, Steven
AU - Zaninovic, Vladimir
AU - Mora, Carlos
AU - Rodgers‐Johnson, Pamela
AU - Sheremata, William A.
AU - Gibbs, Clarence J.
AU - Gajdusek, D. Carleton
AU - McFarlin, Dale E.
PY - 1988
Y1 - 1988
N2 - A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.
AB - A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.
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U2 - 10.1002/ana.410230744
DO - 10.1002/ana.410230744
M3 - Article
C2 - 2894814
AN - SCOPUS:0023750021
VL - 23
SP - S196-S200
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 1 S
ER -