Immunologic studies of peripheral blood lymphocytes and lymph nodes in Hodgkin's disease. A preliminary report

J. R. Cunningham, R. M. Bukowski, R. Valenzuela, R. Tubbs

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphocytes (PBL) and lymph nodes from patients with newly diagnosed and untreated Hodgkin's disease were studied to determine the distribution of T lymphocytes. Fluorescence-activated cell sorting of PBL was performed on 11 out of 12 patients using monoclonal antibodies to lymphocyte differentiation antigens. A reduction in T lymphocytes (anti-T3) was found in 5 patients, a reduction of T4 lymphocytes was found in 3 patients, and an increase in the PBL T8 cells occurred in 1 patient. In three cases, the T4:T8 PBL ratio was decreased. Complete staging was performed on all 12 patients. No correlation between clinical stage and T-cell subpopulations was apparent. Evidence of sustained immune depletion was found in 1 patient at relapse. Efforts to monitor immune function in Hodgkin's disease should continue and may provide a data base from which immunopathologic staging can be developed.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalCleveland Clinic Quarterly
Volume52
Issue number1
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

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