Immunologic regulation of toll-like receptors in gut epithelium

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose of review: In response to the presence of pathogens in the environment, the innate immune system has evolved to provide a rapid defense against microbes. This response involves the recognition of molecular patterns present in diverse microbes by a series of receptors termed toll-like receptors. The focus of this article is the regulation of toll-like receptor signaling in the intestinal epithelium. The intestinal epithelium is continually exposed to a high concentration of diverse bacteria. In spite of the density of commensal bacteria, the normal intestine is not inflamed. Idiopathic inflammatory bowel disease in humans and animals is characterized by aberrant host-microbial interactions. Recent findings: Several studies demonstrate that intestinal epithelial cells are poorly responsive to microbial products. The reason for this hyporesponsiveness is decreased or polarized expression of toll-like receptor molecules. Inflammatory cytokines upregulate expression of toll-like receptors. Summary: The intestinal epithelium has evolved under the pressure of the microbiota to mute a response to commensal bacteria while maintaining the ability to respond to pathogens. In inflammatory bowel disease, the loss of tolerance to the normal flora may be due in part to inappropriate toll-like receptor signaling.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume19
Issue number6
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

Fingerprint

Toll-Like Receptors
Epithelium
Intestinal Mucosa
Bacteria
Inflammatory Bowel Diseases
Microbial Interactions
Microbiota
Intestines
Immune System
Up-Regulation
Epithelial Cells
Cytokines
Pressure

Keywords

  • Inflammatory bowel disease
  • Innate immunity
  • Lipopolysaccharide
  • NF-κB
  • NOD1
  • NOD2
  • Toll-like receptors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Immunologic regulation of toll-like receptors in gut epithelium. / Abreu, Maria T.

In: Current Opinion in Gastroenterology, Vol. 19, No. 6, 01.11.2003, p. 559-564.

Research output: Contribution to journalArticle

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