Immunologic Mechanisms in Experimental Encephalomyelitis in Nonhuman Primates

Peter O. Behan, Marian W. Kies, Robert P. Lisak, William Sheremata, Jacques B. Lamarche

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Experimental allergic encephalomyelitis was induced in large rhesus monkeys by immunizing them with homologous and heterologous myelin basic proteins in different adjuvants. Two clinically and pathologically different types of disease, ordinary and hyperacute, were produced. In both types cell mediated hypersensitivity was demonstrated to a variety of myelin basic proteins from different species by in vivo and in vitro techniques. Humoral antibody to homologous myelin basic protein could only be found in the fulminant hyperacute form.

Original languageEnglish (US)
Pages (from-to)4-9
Number of pages6
JournalArchives of neurology
Issue number1
StatePublished - Jul 1973

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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