Immunologic and Serologic Studies in a Child with Associated HIV Infection

Marianne Frieri, Anat Warren, Linda Pozner, Nathan Weiss, Savita G Pahwa

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 15-month-old black male infant of drug-abusing parents presented with failure to thrive, lymphadenopathy, hepatosplenomegaly, and interstitial pneumonia. At 4 years, oral candidiasis, purulent otitis, and recurrent cryptococcal meningitis developed. Abnormal cerebrospinal fluid (CSF) values, along with lymphocytosis, anemia, and elevations in immunoglobulins, β2-microglobulin, and viral antibody levels against human immunodeficiency virus (HIV), Epstein—Barr virus, and cytomegalovirus were also observed. The viral culture for HIV was also positive. Cryptococcus neoformans (Cn) was repeatedly isolated from the CSF. An initial positive culture and elevated antigen titer to Cn corresponded to markedly suppressed T-lymphocyte responses. Improved T-cell function and a negative Cn culture occurred with therapy, although in vitro B-cell responsiveness and the CD4/CD8 ratio remained low. The reappearance of a positive Cn culture, despite declining serum antigen titers was associated with markedly suppressed T-cell function. In this case, a decline in T-cell responsiveness appears to have been predictive of recurrent cryptococcal disease.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalPediatric Asthma, Allergy and Immunology
Issue number4
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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