TY - JOUR
T1 - Immunolocalization of connexin 26 in the developing mouse cochlea
AU - Frenz, Christopher M.
AU - Van De Water, Thomas R.
PY - 2000/3/24
Y1 - 2000/3/24
N2 - Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell-cell communication. In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane). (C) 2000 Elsevier Science B.V.
AB - Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell-cell communication. In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane). (C) 2000 Elsevier Science B.V.
KW - Cochlea
KW - Connexin 26
KW - Development
KW - Gap junction
UR - http://www.scopus.com/inward/record.url?scp=0034109489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034109489&partnerID=8YFLogxK
U2 - 10.1016/S0165-0173(99)00078-8
DO - 10.1016/S0165-0173(99)00078-8
M3 - Review article
C2 - 10751667
AN - SCOPUS:0034109489
VL - 32
SP - 172
EP - 180
JO - Brain Research Reviews
JF - Brain Research Reviews
SN - 0165-0173
IS - 1
ER -