Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets

Ronald S. Hill, Greg M. Cruise, Steve R. Hager, Francis V. Lamberti, Xiaojie Yu, Carrie L. Garufis, Yao Yu, Karen E. Mundwiler, John F. Cole, Jeffery A. Hubbell, Orion D. Hegre, David W. Scharp

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).

Original languageEnglish (US)
Pages (from-to)332-343
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume831
DOIs
StatePublished - Dec 31 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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