Immunohistochemical Margin Control Applied to Mohs Micrographic Surgical Excision of Dermatofibrosarcoma Protuberans

FRANCISCO JAVIER JIMENEZ, JAMES MICHAEL GRICHNIK, MARK DEWAINE BUCHANAN, ROBERT EARL CLARK

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

BACKGROUND. Surgical treatment of dermatofibrosarcoma protuberans has a high rate of recurrence presumably secondary to persistent residual tumor. Recently an antigenic marker, CD34, has demonstrated specificity for this tumor. OBJECTIVE. To improve the microscopic detection of dermatofibrosarcoma protuberans tumor elements in Mohs micrographic surgical sections by incorporating immunohistologic staining. METHODS. Standard Mohs micrographic surgical technique was used, coupled with standard immunohistochemical procedures using an antibody to the CD34 antigen. RESULTS. Immunohistochemical staining with anti-CD34 of Mohs micrographic sections clearly delineated the extent of the tumor elements. CONCLUSIONS. We anticipate that the application of this immunohistochemical-modified Mohs surgical technique will further enhance the detection of insidious portions of tumor thereby enhancing removal and reducing recurrence.

Original languageEnglish (US)
Pages (from-to)687-689
Number of pages3
JournalThe Journal of Dermatologic Surgery and Oncology
Volume20
Issue number10
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Oncology
  • Dermatology

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