Recently, it has been shown that somatostatin, a hypothalamic hormone which inhibits the release of growth hormone and thyrotropin (3, 4), can also inhibit the secretion of both insulin and glucagon (5, 10). Since this action of somatostatin has been shown in isolated dog and rat pancreas, a direct action of somatostatin on the endocrine pancreas has been postulated. At the light microscope level, a positive reaction for somatostatin was found only in a few cells of the Langerhans islets. These cells had an irregular shape and were more commonly located at the periphery of the islets. No specific staining was found in the exocrine pancreas. No specific staining was obtained when normal rabbit serum or antisomatostatin serum adsorbed by synthetic somatostatin (10-5 M) was used, thus indicating the specificity of the reaction.
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