Immunohistochemical localization of somatostatin in endocrine cells of the rat stomach

R. Leclerc, G. Pelletier, R. Puviani, A. Arimura, A. V. Schally

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Using an immunohistochemical technique involving unlabeled antibody and the peroxidaseanti-peroxidase complex, we have localized somatostatin (or growth hormone-release inhibiting hormone), a hypothalamic hormone which can also inhibit gastrin secretion, in the rat stomach. Somatostatin was found to be present in a few cells in the mucosa of the pyloric antrum. These cells are characterized by the presence of secretory granules of about 150-250 nm in diameter and are probably endocrine cells.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalMolecular and Cellular Endocrinology
Issue number4
StatePublished - Mar 1976
Externally publishedYes


  • gastrin
  • hypothalamus
  • immunohistochemistry
  • stomatostatin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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