Immunohistochemical localization of luteinizing hormone-releasing hormone in the rat median eminence

G. Pelletier, F. Labrie, R. Puviani, A. Arimura, A. V. Schally

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Although it has been shown that hypothalamic neurohormones controlling adenohypophyseal activity are concentrated in the median eminence, precise identification of the intracellular structures containing hypophysiotropic hormones has as yet not been achieved. Using an immunohistochemical technique at the electron microscopic level, it was observed that luteinizing hormone releasing hormone (LH-RH), the neurohormone stimulating the release of both FSH and LH, is contained in the secretory granules of some nerve endings located in the palisade layer of the median eminence. This is the first demonstration at the ultrastructural level that an hypothalamic releasing hormone is stored in secretory granules of the median eminence.

Original languageEnglish (US)
Pages (from-to)314-317
Number of pages4
Issue number1
StatePublished - Jul 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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