Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues

Haim Matzkin, Mark S. Soloway

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Estrogens may be involved in normal growth of the prostate and the development of benign prostatic hyperplasia (BPH). The location of estrogen production is still unclear, and there has never been a direct evidence for the existence of the aromatase system, which converts androgens to estrogens, in the prostate. Using an avidin-biotin technique with a polyclonal anti-human placental aromatase, we demonstrated the existence of aromatase in normal prostates of young men and BPH tissue from elderly men. The staining is more pronounced in the stroma. However, positive stains were also seen in the glandular epithelium. While evidence of the existence of an enzyme system does not equal demonstration of its activity in a specific tissue site, our findings suggest that local estrogen production in the stroma and or epithelium of the prostate may play a role in the maintenance of normal growth and development of BPH.

Original languageEnglish (US)
Pages (from-to)309-314
Number of pages6
JournalThe Prostate
Volume21
Issue number4
DOIs
StatePublished - 1992

Keywords

  • aromatase
  • immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Urology

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