Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism

David T. Evans, Marian S. Piekarczyk, Todd M. Allen, Jonathan E. Boyson, Meredith Yeager, Austin L. Hughes, Frances M. Gotch, Virginia S. Hinshaw, David Watkins

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

MHC class I molecules play a crucial role in immunity to viral infections by presenting viral peptides to cytotoxic T lymphocytes. One of the hallmarks of MHC class I genes in outbred populations is their extraordinary polymorphism, yet the significance of this diversity is poorly understood. Certain species with reduced MHC class I diversity, such as the cotton-top tamarin (Saguinus oedipus), are more susceptible to fatal viral infections. To explore the relationship between this primate's limited MHC class I diversity and its susceptibility to viruses, we infected five cotton-top tamarins with influenza virus. Every tamarin recognized the same immunodominant CTL epitope of the influenza nucleoprotein. Surprisingly, this nucleoprotein peptide was bound by Saoe-C*08, an MHC class I molecule expressed by every cotton-top tamarin. Two tamarins also made a subdominant response to an epitope of the matrix (M1) protein. This peptide appeared to be bound by another common MHC class I molecule. With the exception of an additional subdominant response to the polymerase (PB2) protein in one individual, no other influenza-specific CTL responses were detected. In populations or species with limited MHC class I polymorphism like the cotton-top tamarin, a dependence on shared MHC class I molecules may enhance susceptibility to viral infection, since viruses that evade MHC class I-restricted recognition in one individual will likely evade recognition in the majority of individuals.

Original languageEnglish
Pages (from-to)1374-1382
Number of pages9
JournalJournal of Immunology
Volume159
Issue number3
StatePublished - Aug 1 1997
Externally publishedYes

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Virus Diseases
Primates
Epitopes
Nucleoproteins
Peptides
Human Influenza
Saguinus
Viruses
MHC Class I Genes
Immunodominant Epitopes
Cytotoxic T-Lymphocytes
Orthomyxoviridae
Population
Immunity
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Evans, D. T., Piekarczyk, M. S., Allen, T. M., Boyson, J. E., Yeager, M., Hughes, A. L., ... Watkins, D. (1997). Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism. Journal of Immunology, 159(3), 1374-1382.

Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism. / Evans, David T.; Piekarczyk, Marian S.; Allen, Todd M.; Boyson, Jonathan E.; Yeager, Meredith; Hughes, Austin L.; Gotch, Frances M.; Hinshaw, Virginia S.; Watkins, David.

In: Journal of Immunology, Vol. 159, No. 3, 01.08.1997, p. 1374-1382.

Research output: Contribution to journalArticle

Evans, DT, Piekarczyk, MS, Allen, TM, Boyson, JE, Yeager, M, Hughes, AL, Gotch, FM, Hinshaw, VS & Watkins, D 1997, 'Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism', Journal of Immunology, vol. 159, no. 3, pp. 1374-1382.
Evans DT, Piekarczyk MS, Allen TM, Boyson JE, Yeager M, Hughes AL et al. Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism. Journal of Immunology. 1997 Aug 1;159(3):1374-1382.
Evans, David T. ; Piekarczyk, Marian S. ; Allen, Todd M. ; Boyson, Jonathan E. ; Yeager, Meredith ; Hughes, Austin L. ; Gotch, Frances M. ; Hinshaw, Virginia S. ; Watkins, David. / Immunodominance of a Single CTL Epitope in a Primate Species with Limited MHC Class I Polymorphism. In: Journal of Immunology. 1997 ; Vol. 159, No. 3. pp. 1374-1382.
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