Abstract
The distribution of corticotropin releasing factor (CRF)-immunoreactive structures in the rat thalamus was studied after treatment with high doses of colchicine (100 μg/100 g b.wt.) with peroxidase-antiperoxidase (PAP) immunocytochemistry in vibratome sections. CRF-immunopositive perikarya were found in the 'posteromedial complex' of the thalamus, including the ventromedial, paracentral, mediodorsal, rhomboid, parafascicular nuclei, centrum medianum and ventromedial portion of the posterolateral nucleus. In addition, CRF-containing perikarya were observed in the pretectal and subthalamic nuclei. CRF-immunoreactive processes were seen in most of the medial nuclei of the thalamus. The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and β-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.
| Original language | English |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 323 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 3 1984 |
| Externally published | Yes |
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Keywords
- analgesia
- hypophysiotrophic hormone
- mapping of corticotropin releasing factor
- nociception
- pain
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Immunocytochemical localization of corticotropin releasing factor (CRF)-like immunoreactivity in the thalamus of the rat. / Merchenthaler, I.; Vigh, S.; Schally, Andrew V; Stumpf, W. E.; Arimura, A.
In: Brain Research, Vol. 323, No. 1, 03.12.1984, p. 119-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunocytochemical localization of corticotropin releasing factor (CRF)-like immunoreactivity in the thalamus of the rat
AU - Merchenthaler, I.
AU - Vigh, S.
AU - Schally, Andrew V
AU - Stumpf, W. E.
AU - Arimura, A.
PY - 1984/12/3
Y1 - 1984/12/3
N2 - The distribution of corticotropin releasing factor (CRF)-immunoreactive structures in the rat thalamus was studied after treatment with high doses of colchicine (100 μg/100 g b.wt.) with peroxidase-antiperoxidase (PAP) immunocytochemistry in vibratome sections. CRF-immunopositive perikarya were found in the 'posteromedial complex' of the thalamus, including the ventromedial, paracentral, mediodorsal, rhomboid, parafascicular nuclei, centrum medianum and ventromedial portion of the posterolateral nucleus. In addition, CRF-containing perikarya were observed in the pretectal and subthalamic nuclei. CRF-immunoreactive processes were seen in most of the medial nuclei of the thalamus. The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and β-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.
AB - The distribution of corticotropin releasing factor (CRF)-immunoreactive structures in the rat thalamus was studied after treatment with high doses of colchicine (100 μg/100 g b.wt.) with peroxidase-antiperoxidase (PAP) immunocytochemistry in vibratome sections. CRF-immunopositive perikarya were found in the 'posteromedial complex' of the thalamus, including the ventromedial, paracentral, mediodorsal, rhomboid, parafascicular nuclei, centrum medianum and ventromedial portion of the posterolateral nucleus. In addition, CRF-containing perikarya were observed in the pretectal and subthalamic nuclei. CRF-immunoreactive processes were seen in most of the medial nuclei of the thalamus. The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and β-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.
KW - analgesia
KW - hypophysiotrophic hormone
KW - mapping of corticotropin releasing factor
KW - nociception
KW - pain
UR - http://www.scopus.com/inward/record.url?scp=0021691490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021691490&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(84)90272-5
DO - 10.1016/0006-8993(84)90272-5
M3 - Article
C2 - 6151862
AN - SCOPUS:0021691490
VL - 323
SP - 119
EP - 122
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -