Immunocytochemical localization of corticotropin releasing factor (CRF)-like immunoreactivity in the thalamus of the rat

I. Merchenthaler, S. Vigh, Andrew V Schally, W. E. Stumpf, A. Arimura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The distribution of corticotropin releasing factor (CRF)-immunoreactive structures in the rat thalamus was studied after treatment with high doses of colchicine (100 μg/100 g b.wt.) with peroxidase-antiperoxidase (PAP) immunocytochemistry in vibratome sections. CRF-immunopositive perikarya were found in the 'posteromedial complex' of the thalamus, including the ventromedial, paracentral, mediodorsal, rhomboid, parafascicular nuclei, centrum medianum and ventromedial portion of the posterolateral nucleus. In addition, CRF-containing perikarya were observed in the pretectal and subthalamic nuclei. CRF-immunoreactive processes were seen in most of the medial nuclei of the thalamus. The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and β-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalBrain Research
Volume323
Issue number1
DOIs
StatePublished - Dec 3 1984
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Thalamus
Intralaminar Thalamic Nuclei
Neurotransmitter Agents
Midline Thalamic Nuclei
Pituitary Hormone-Releasing Hormones
Endorphins
Subthalamic Nucleus
Nociception
Colchicine
Adrenocorticotropic Hormone
Analgesia
Peroxidase
Immunohistochemistry

Keywords

  • analgesia
  • hypophysiotrophic hormone
  • mapping of corticotropin releasing factor
  • nociception
  • pain

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immunocytochemical localization of corticotropin releasing factor (CRF)-like immunoreactivity in the thalamus of the rat. / Merchenthaler, I.; Vigh, S.; Schally, Andrew V; Stumpf, W. E.; Arimura, A.

In: Brain Research, Vol. 323, No. 1, 03.12.1984, p. 119-122.

Research output: Contribution to journalArticle

Merchenthaler, I. ; Vigh, S. ; Schally, Andrew V ; Stumpf, W. E. ; Arimura, A. / Immunocytochemical localization of corticotropin releasing factor (CRF)-like immunoreactivity in the thalamus of the rat. In: Brain Research. 1984 ; Vol. 323, No. 1. pp. 119-122.
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