Immunocytochemical evidence of heterogenous origin of α-fetoprotein in immature teratoma of the ovary

David R. Burrus; Takashi Okagaki; Leo B. Twiggs; Doris C. Brooker

doi:10.1016/0090-8258(85)90234-3

Immunocytochemical evidence of heterogenous origin of α-fetoprotein in immature teratoma of the ovary

David R. Burrus, Takashi Okagaki, Leo B. Twiggs, Doris C. Brooker

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	Gynecologic oncology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/0090-8258(85)90234-3
State	Published - May 1985

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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title = "Immunocytochemical evidence of heterogenous origin of α-fetoprotein in immature teratoma of the ovary",

abstract = "α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.",

author = "Burrus, {David R.} and Takashi Okagaki and Twiggs, {Leo B.} and Brooker, {Doris C.}",

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AU - Burrus, David R.

AU - Okagaki, Takashi

AU - Twiggs, Leo B.

AU - Brooker, Doris C.

PY - 1985/5

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AB - α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.

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