Abstract
α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.
| Original language | English |
|---|---|
| Pages (from-to) | 73-79 |
| Number of pages | 7 |
| Journal | Gynecologic Oncology |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
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Immunocytochemical evidence of heterogenous origin of α-fetoprotein in immature teratoma of the ovary. / Burrus, David R.; Okagaki, Takashi; Twiggs, Leo B.; Brooker, Doris C.
In: Gynecologic Oncology, Vol. 21, No. 1, 01.01.1985, p. 73-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunocytochemical evidence of heterogenous origin of α-fetoprotein in immature teratoma of the ovary
AU - Burrus, David R.
AU - Okagaki, Takashi
AU - Twiggs, Leo B.
AU - Brooker, Doris C.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.
AB - α-Fetoprotein (AFP) has been found to be clinically important in the management of patients with gynecologic malignancies. Serum AFP levels are used as tumor markers for ovarian tumors, namely endodermal sinus tumors (EST) and embryonal tumors. In two cases of immature teratoma of the ovary without a yolk sac component, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin suggesting a heterogeneous origin of AFP. To complement this finding, a summary of the ontology of AFP along with current and potential uses of an antigenically active tumor marker are presented.
UR - http://www.scopus.com/inward/record.url?scp=0021894866&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021894866&partnerID=8YFLogxK
U2 - 10.1016/0090-8258(85)90234-3
DO - 10.1016/0090-8258(85)90234-3
M3 - Article
C2 - 2580759
AN - SCOPUS:0021894866
VL - 21
SP - 73
EP - 79
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -