Immunochemical studies of infectious mononucleosis. III. Isolation and characterization of heterophile antibodies

M. A. Fletcher, T. M. Lo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The heterophile antibody of infectious mononucleosis was isolated using an immunoabsorbent containing highly purified glycoprotein from horse erythrocyte membrane. Only the IgM fraction of this antibody agglutinated sheep erythrocytes or precipitated with the heterophile antigens from sheep, ox or horse red cells. The IgM antibody contained both kappa and lambda light chain determinants. The only reactivity which could be attributed to the IgG fraction of infectious mononucleosis serum was a slight degree of antigen binding by indirect radioimmunoelectrophoresis using 131I labelled horse erythrocyte glycoprotein.

Original languageEnglish (US)
Pages (from-to)607-614
Number of pages8
JournalClinical and Experimental Immunology
Volume16
Issue number4
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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