Immunochemical demonstration of immunoreactive insulin in human breast cancer

A. Castro, J. Ziegels-Weissman, P. Buschbaum, W. Voigt, A. Morales, M. Nadji

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The immunoreactive insulin contents of the cytosol extracts of 57 human mammary carcinomas were measured by specific radioimmunoassay. All of these extracts contained measurable insulin (detection limit 1.3 ng/g tumor). In some cases (23) the levels were quite greater than the normal human serum levels. Immunoperoxidase technique revealed the presence of immunoreactive insulin within the cytoplasm of tumor cells in 6 cases.

Original languageEnglish (US)
Pages (from-to)171-182
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
StatePublished - Sep 12 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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