Immunochemical demonstration of immunoreactive insulin in human breast cancer

A. Castro, J. Ziegels-Weissman, P. Buschbaum, W. Voigt, Azorides R Morales, Mehrdad Nadji

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The immunoreactive insulin contents of the cytosol extracts of 57 human mammary carcinomas were measured by specific radioimmunoassay. All of these extracts contained measurable insulin (detection limit 1.3 ng/g tumor). In some cases (23) the levels were quite greater than the normal human serum levels. Immunoperoxidase technique revealed the presence of immunoreactive insulin within the cytoplasm of tumor cells in 6 cases.

Original languageEnglish
Pages (from-to)171-182
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume29
Issue number1
StatePublished - Sep 12 1980
Externally publishedYes

Fingerprint

Demonstrations
Insulin
Breast Neoplasms
Tumors
Immunoenzyme Techniques
Cytosol
Radioimmunoassay
Limit of Detection
Neoplasms
Cytoplasm
Cells
Serum

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Castro, A., Ziegels-Weissman, J., Buschbaum, P., Voigt, W., Morales, A. R., & Nadji, M. (1980). Immunochemical demonstration of immunoreactive insulin in human breast cancer. Research Communications in Chemical Pathology and Pharmacology, 29(1), 171-182.

Immunochemical demonstration of immunoreactive insulin in human breast cancer. / Castro, A.; Ziegels-Weissman, J.; Buschbaum, P.; Voigt, W.; Morales, Azorides R; Nadji, Mehrdad.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 29, No. 1, 12.09.1980, p. 171-182.

Research output: Contribution to journalArticle

Castro, A, Ziegels-Weissman, J, Buschbaum, P, Voigt, W, Morales, AR & Nadji, M 1980, 'Immunochemical demonstration of immunoreactive insulin in human breast cancer', Research Communications in Chemical Pathology and Pharmacology, vol. 29, no. 1, pp. 171-182.
Castro, A. ; Ziegels-Weissman, J. ; Buschbaum, P. ; Voigt, W. ; Morales, Azorides R ; Nadji, Mehrdad. / Immunochemical demonstration of immunoreactive insulin in human breast cancer. In: Research Communications in Chemical Pathology and Pharmacology. 1980 ; Vol. 29, No. 1. pp. 171-182.
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