Immunobiology of the cotton-top tamarin

David Watkins, Norman L. Letvin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The cotton-top tamarin (Saguinus oedipus) has been widely used as a model in biomedical research to study the pathogenesis of certain human diseases. 1 The reason for using this particular species stems, in part, from its extreme susceptibility to a variety of viruses. S. oedipus develops fatal lymphoproliferative syndromes following infections with Epstein-Barr virus (EBV) 2 and Herpesvirus saimiri, 3 The cotton-top tamarin also appears to be far more susceptible to retrovirus-induced sarcomas and fatal measle virus infections than other species. 4, 5 Additionally, as many as 60% of captive S. oedipus spontaneously develop ulcerative colitis and 15% develop adenocarcinoma of the colon.

Original languageEnglish (US)
Title of host publicationA Primate Model for the Study of Colitis and Colonic Carcinoma the Cotton-Top Tamarin (Saguinus oedipus)
PublisherCRC Press
Pages295-308
Number of pages14
ISBN (Electronic)9781351077866
ISBN (Print)0849353637, 9781315890319
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Watkins, D., & Letvin, N. L. (2018). Immunobiology of the cotton-top tamarin. In A Primate Model for the Study of Colitis and Colonic Carcinoma the Cotton-Top Tamarin (Saguinus oedipus) (pp. 295-308). CRC Press. https://doi.org/10.1201/9781351069410