Abstract
The cotton-top tamarin (Saguinus oedipus) has been widely used as a model in biomedical research to study the pathogenesis of certain human diseases. 1 The reason for using this particular species stems, in part, from its extreme susceptibility to a variety of viruses. S. oedipus develops fatal lymphoproliferative syndromes following infections with Epstein-Barr virus (EBV) 2 and Herpesvirus saimiri, 3 The cotton-top tamarin also appears to be far more susceptible to retrovirus-induced sarcomas and fatal measle virus infections than other species. 4, 5 Additionally, as many as 60% of captive S. oedipus spontaneously develop ulcerative colitis and 15% develop adenocarcinoma of the colon.
Original language | English (US) |
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Title of host publication | A Primate Model for the Study of Colitis and Colonic Carcinoma the Cotton-Top Tamarin (Saguinus oedipus) |
Publisher | CRC Press |
Pages | 295-308 |
Number of pages | 14 |
ISBN (Electronic) | 9781351077866 |
ISBN (Print) | 0849353637, 9781315890319 |
DOIs | |
State | Published - Jan 1 2018 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)