Immune responsiveness of splenocytes after chronic daily melatonin administration in male syrian hamsters

Thomas H. Champney, Jessica Prado, Tonya Youngblood, Kevin Appel, David N. McMurray

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The interrelationships between the immune system and the pineal hormone, melatonin, have been explored recently. The present studies investigated ted the effects of daily melatonin injections on reproductive and spleen function in male Syrian hamsters. Testes weights and serum testosterone levels were depressed after 8-10 weeks of daily melatonin injections. Melatonin-treated hamsters exhibited increased splenic lymphoproliferative responses to a polyclonal T-cell mitogen (concanavalin A (Con-A)), but decreased proliferation following stimulation with a polyclonal B-cell mitogen (lipopolysaccharide). It appears that daily melatonin injections in male hamsters increase the T-cell-mediated immune capacity while reducing the antibody-mediated immune potential. These data suggest that chronic, daily melatonin alters immune system responsiveness in hamsters by shifting the balance of cellular and humoral reactivity.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalImmunology Letters
Volume58
Issue number2
DOIs
StatePublished - Jul 1 1997
Externally publishedYes

Keywords

  • Hamster
  • Immune
  • Lymphoproliferation
  • Melatonin
  • Spleen

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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