Immune responsiveness of splenocytes after chronic daily melatonin administration in male syrian hamsters

Thomas H. Champney; Jessica Prado; Tonya Youngblood; Kevin Appel; David N. McMurray

doi:10.1016/S0165-2478(97)00039-4

Immune responsiveness of splenocytes after chronic daily melatonin administration in male syrian hamsters

Thomas H. Champney, Jessica Prado, Tonya Youngblood, Kevin Appel, David N. McMurray

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The interrelationships between the immune system and the pineal hormone, melatonin, have been explored recently. The present studies investigated ted the effects of daily melatonin injections on reproductive and spleen function in male Syrian hamsters. Testes weights and serum testosterone levels were depressed after 8-10 weeks of daily melatonin injections. Melatonin-treated hamsters exhibited increased splenic lymphoproliferative responses to a polyclonal T-cell mitogen (concanavalin A (Con-A)), but decreased proliferation following stimulation with a polyclonal B-cell mitogen (lipopolysaccharide). It appears that daily melatonin injections in male hamsters increase the T-cell-mediated immune capacity while reducing the antibody-mediated immune potential. These data suggest that chronic, daily melatonin alters immune system responsiveness in hamsters by shifting the balance of cellular and humoral reactivity.

Original language	English (US)
Pages (from-to)	95-100
Number of pages	6
Journal	Immunology Letters
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/S0165-2478(97)00039-4
State	Published - Jul 1 1997
Externally published	Yes

Keywords

Hamster
Immune
Lymphoproliferation
Melatonin
Spleen

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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abstract = "The interrelationships between the immune system and the pineal hormone, melatonin, have been explored recently. The present studies investigated ted the effects of daily melatonin injections on reproductive and spleen function in male Syrian hamsters. Testes weights and serum testosterone levels were depressed after 8-10 weeks of daily melatonin injections. Melatonin-treated hamsters exhibited increased splenic lymphoproliferative responses to a polyclonal T-cell mitogen (concanavalin A (Con-A)), but decreased proliferation following stimulation with a polyclonal B-cell mitogen (lipopolysaccharide). It appears that daily melatonin injections in male hamsters increase the T-cell-mediated immune capacity while reducing the antibody-mediated immune potential. These data suggest that chronic, daily melatonin alters immune system responsiveness in hamsters by shifting the balance of cellular and humoral reactivity.",

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AU - McMurray, David N.

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