Immune responses to nervous system decentralization and exercise in quadriplegia

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Interactions among the nervous, neuroendocrine, and immune systems render host defenses highly sensitive to autonomic over- or understimulation. Persons with quadriplegia experience decentralization of directly innervated immune tissues and neuroendocrine axis dysregulation, immobilization deconditioning, heightened exposure to immune suppressing xerobiologicals, and psychic and nonpsychic stressors differing from those of nondisabled cohorts. When compared with matched nondisabled controls, young survivors of quadriplegia have reduced CD4:CD8 ratios, suppressed proliferative responses to mitogen challenge, reduced number and cytotoxicity of CD3-CD56+ (NK) cells, and elevation of the soluble IL-2 receptor. Deviations from control values are typically observed in persons with injuries higher than sympathetic outflow, suggesting a cause related to autonomic dysfunction. Cycling exercise performed by persons with quadriplegia using computer- sequenced electrically stimulated contraction of the quadriceps, hamstring, and gluteus muscle groups fails to provoke an archetypical leukocytosis, but transitionally elevates NK cell number and cytotoxicity lasting one-half hour after exercise. These findings show that the immune system of persons with quadriplegia is selectively responsive to exercise challenge. As opportunistic infections of the urinary tract, lungs, and skin are major causes of morbidity in survivors of quadriplegia, these observations may identify a treatment through which their host defenses can be fortified.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume26
Issue number2
StatePublished - Jan 1 1994

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Quadriplegia
Politics
Nervous System
Exercise
Natural Killer Cells
Survivors
Immune System
CD4-CD8 Ratio
Neurosecretory Systems
Interleukin-2 Receptors
Leukocytosis
Opportunistic Infections
Urinary Tract
Mitogens
Immobilization
Cell Count
Morbidity
Lung
Skin
Wounds and Injuries

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Immune responses to nervous system decentralization and exercise in quadriplegia. / Nash, Mark S.

In: Medicine and Science in Sports and Exercise, Vol. 26, No. 2, 01.01.1994, p. 164-171.

Research output: Contribution to journalArticle

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