Immune responses to complex protein antigens. I. MHC control of immune responses to bovine albumin

Richard L Riley, L. D. Wilson, R. N. Germain, D. C. Benjamin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Murine T cell proliferative and antibody responses to the multi-determinant protein bovine serum albumin (BSA) are controlled by Ir genes mapping within the H-2 gene complex. Strains possessing the H-2(k), H-2a, and H-2(d) haplotypes are classified as high responders to BSA. In contrast, H-2b strains are low responders to BSA. Genetic mapping experiments employing strains with recombinant H-2 haplotypes indicate that both T cell proliferative and antibody responses are at least in part regulated by genes within the I-A subregion. Studies on the inhibition of T cell proliferation by monoclonal anti-Ia antibodies are consistent with the assignment of an Ir gene for BSA to the I-A subregion and strongly suggest a role for genes within the I-E/C subregions as well. The MHC-mediated control of antibody responses did not affect the affinity or the isotype of the antibody produced. The relative quantities of antibody specific for each of the three domains of BSA appears to be regulated by H-2-linked BSA Ir genes, and domain III antigenic determinants were found to be dominant in the responses of low-responder mice and in the early response of high-responder mice. This domain III epitope dominance essentially disappears by the tertiary response of high-responder mice.

Original languageEnglish
Pages (from-to)1553-1558
Number of pages6
JournalJournal of Immunology
Volume129
Issue number4
StatePublished - Jan 1 1982
Externally publishedYes

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Bovine Serum Albumin
Albumins
Antigens
Antibody Formation
Proteins
Genes
T-Lymphocytes
Haplotypes
Epitopes
Antibodies
Chromosome Mapping
Anti-Idiotypic Antibodies
Monoclonal Antibodies
Cell Proliferation

ASJC Scopus subject areas

  • Immunology

Cite this

Immune responses to complex protein antigens. I. MHC control of immune responses to bovine albumin. / Riley, Richard L; Wilson, L. D.; Germain, R. N.; Benjamin, D. C.

In: Journal of Immunology, Vol. 129, No. 4, 01.01.1982, p. 1553-1558.

Research output: Contribution to journalArticle

Riley, Richard L ; Wilson, L. D. ; Germain, R. N. ; Benjamin, D. C. / Immune responses to complex protein antigens. I. MHC control of immune responses to bovine albumin. In: Journal of Immunology. 1982 ; Vol. 129, No. 4. pp. 1553-1558.
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