Immune responses in the bicolor damselfish, Pomacentrus partitus, and their potential role in the development of neurogenic tumours

Michael C Schmale, E. C. Mckinney

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bicolor damselfish on southern Florida reefs are commonly affected by a disease consisting of Schwann cell tumours. Several features of this disease, termed damselfish neurofibromatosis (DNF), indicate that the immune system of these fish may play an important role in the expression and rate of progression of the tumours. The majority of fish in the advanced stages of DNF showed abnormal, presumably degenerative, histological changes in both the spleen and kidney, suggesting that a general, non‐specific suppression of immune responses might be occurring. This hypothesis was supported by results of mitogen‐induced proliferation and mixed leucocyte responses in fish with DNF which indicated a near total failure of several functions of the immune system involving the pronephros and the spleen. A sparse infiltrate of granulocytes and monocyte/macrophages was seen in these tumours.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalJournal of Fish Biology
Volume31
DOIs
StatePublished - 1987

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Neurofibromatoses
Pomacentridae
immune response
tumor
Fishes
immune system
neoplasms
Immune System
Pronephros
Spleen
fish
Neoplasms
spleen
Schwann Cells
Granulocytes
Schwann cells
Monocytes
Leukocytes
reef
granulocytes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Medicine(all)
  • Aquatic Science

Cite this

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abstract = "Bicolor damselfish on southern Florida reefs are commonly affected by a disease consisting of Schwann cell tumours. Several features of this disease, termed damselfish neurofibromatosis (DNF), indicate that the immune system of these fish may play an important role in the expression and rate of progression of the tumours. The majority of fish in the advanced stages of DNF showed abnormal, presumably degenerative, histological changes in both the spleen and kidney, suggesting that a general, non‐specific suppression of immune responses might be occurring. This hypothesis was supported by results of mitogen‐induced proliferation and mixed leucocyte responses in fish with DNF which indicated a near total failure of several functions of the immune system involving the pronephros and the spleen. A sparse infiltrate of granulocytes and monocyte/macrophages was seen in these tumours.",
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AB - Bicolor damselfish on southern Florida reefs are commonly affected by a disease consisting of Schwann cell tumours. Several features of this disease, termed damselfish neurofibromatosis (DNF), indicate that the immune system of these fish may play an important role in the expression and rate of progression of the tumours. The majority of fish in the advanced stages of DNF showed abnormal, presumably degenerative, histological changes in both the spleen and kidney, suggesting that a general, non‐specific suppression of immune responses might be occurring. This hypothesis was supported by results of mitogen‐induced proliferation and mixed leucocyte responses in fish with DNF which indicated a near total failure of several functions of the immune system involving the pronephros and the spleen. A sparse infiltrate of granulocytes and monocyte/macrophages was seen in these tumours.

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