Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response

Andrea Kovacs, Grace Montepiedra, Vincent Carey, Savita Pahwa, Adriana Weinberg, Lisa Frenkel, Edmund Capparelli, Lynne Mofenson, Elizabeth Smith, Kenneth McIntosh, Sandra K. Burchett

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18 Scopus citations

Abstract

We assessed CD4 cell recovery in 175 children with advanced human immunodeficiency virus disease who had received a 4-drug antiretroviral regimen and were categorized as viral load (VL) responders (VLRs), partial VLRs, or non-VLRs. Median CD4 cell counts increased from baseline to week 48, and, among children with maximal follow-up, increases in CD4 cell counts were sustained to week 96 among VLRs and partial VLRs but not among non-VLRs. For VL rebounders still in the study, CD4 cell counts remained increased for 32 weeks after VL rebound. Sustained immunologic benefits can be achieved even with partial VL response in children with advanced disease.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalJournal of Infectious Diseases
Volume192
Issue number2
DOIs
StatePublished - Jul 15 2005

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Kovacs, A., Montepiedra, G., Carey, V., Pahwa, S., Weinberg, A., Frenkel, L., Capparelli, E., Mofenson, L., Smith, E., McIntosh, K., & Burchett, S. K. (2005). Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response. Journal of Infectious Diseases, 192(2), 296-302. https://doi.org/10.1086/430922