Immune-mediated thrombocytopenia of malaria

J. G. Kelton, J. Keystone, J. Moore, G. Denomme, Elaine Tozman, M. Glynn, P. B. Neame, J. Gauldie, J. Jensen

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Abstract

Thrombocytopenia frequently complicates malarial infections but the mechanism has not been elucidated. We studied 28 patients with malarial infections and noted that 16 of 17 thrombocytopenic patients had elevated levels of platelet-associated IgG (PAIgG). In all thrombocytopenic patients studied, the level of PAIgG returned to normal as the platelet count rose to normal levels. To study the mechanism of the elevated platelet-bound IgG, IgG and F(ab') 2 from patients with recurrent Plasmodium falciparum infections was purified and radiolabeled. Labeled and unlabeled P. falciparum antigen was also prepared. IgG did not nonspecifically bind to malaria-damaged platelets. Binding studies with 3H-malarial antigen demonstrated platelets have saturable binding sites for malarial antigen. Increasing concentrations of malarial antigen displaced the 125I-IgG antimalarial antibody from the platelets. The binding of 125I-IgG and 125I-F(ab') 2 was similar and this excluded significant immune complex binding. The thrombocytopenia that complicates at least some malarial infections is caused by immune mechanisms; specific IgG binds to platelet-bound malaria antigen through the Fab portion of the immunoglobulin molecule.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalJournal of Clinical Investigation
Volume71
Issue number4
StatePublished - 1983
Externally publishedYes

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Idiopathic Thrombocytopenic Purpura
Malaria
Immunoglobulin G
Blood Platelets
Antigens
Plasmodium falciparum
Thrombocytopenia
Infection
Immunoglobulin Fab Fragments
Antimalarials
Antigen-Antibody Complex
Platelet Count
Binding Sites
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kelton, J. G., Keystone, J., Moore, J., Denomme, G., Tozman, E., Glynn, M., ... Jensen, J. (1983). Immune-mediated thrombocytopenia of malaria. Journal of Clinical Investigation, 71(4), 832-836.

Immune-mediated thrombocytopenia of malaria. / Kelton, J. G.; Keystone, J.; Moore, J.; Denomme, G.; Tozman, Elaine; Glynn, M.; Neame, P. B.; Gauldie, J.; Jensen, J.

In: Journal of Clinical Investigation, Vol. 71, No. 4, 1983, p. 832-836.

Research output: Contribution to journalArticle

Kelton, JG, Keystone, J, Moore, J, Denomme, G, Tozman, E, Glynn, M, Neame, PB, Gauldie, J & Jensen, J 1983, 'Immune-mediated thrombocytopenia of malaria', Journal of Clinical Investigation, vol. 71, no. 4, pp. 832-836.
Kelton JG, Keystone J, Moore J, Denomme G, Tozman E, Glynn M et al. Immune-mediated thrombocytopenia of malaria. Journal of Clinical Investigation. 1983;71(4):832-836.
Kelton, J. G. ; Keystone, J. ; Moore, J. ; Denomme, G. ; Tozman, Elaine ; Glynn, M. ; Neame, P. B. ; Gauldie, J. ; Jensen, J. / Immune-mediated thrombocytopenia of malaria. In: Journal of Clinical Investigation. 1983 ; Vol. 71, No. 4. pp. 832-836.
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