Immune-mediated thrombocytopenia of malaria

J. G. Kelton, J. Keystone, J. Moore, G. Denomme, E. Tozman, M. Glynn, P. B. Neame, J. Gauldie, J. Jensen

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Thrombocytopenia frequently complicates malarial infections but the mechanism has not been elucidated. We studied 28 patients with malarial infections and noted that 16 of 17 thrombocytopenic patients had elevated levels of platelet-associated IgG (PAIgG). In all thrombocytopenic patients studied, the level of PAIgG returned to normal as the platelet count rose to normal levels. To study the mechanism of the elevated platelet-bound IgG, IgG and F(ab')2 from patients with recurrent Plasmodium falciparum infections was purified and radiolabeled. Labeled and unlabeled P. falciparum antigen was also prepared. IgG did not nonspecifically bind to malaria-damaged platelets. Binding studies with 3H-malarial antigen demonstrated platelets have saturable binding sites for malarial antigen. Increasing concentrations of malarial antigen displaced the 125I-IgG antimalarial antibody from the platelets. The binding of 125I-IgG and 125I-F(ab')2 was similar and this excluded significant immune complex binding. The thrombocytopenia that complicates at least some malarial infections is caused by immune mechanisms; specific IgG binds to platelet-bound malaria antigen through the Fab portion of the immunoglobulin molecule.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalUnknown Journal
Volume71
Issue number4
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Immune-mediated thrombocytopenia of malaria'. Together they form a unique fingerprint.

  • Cite this

    Kelton, J. G., Keystone, J., Moore, J., Denomme, G., Tozman, E., Glynn, M., Neame, P. B., Gauldie, J., & Jensen, J. (1983). Immune-mediated thrombocytopenia of malaria. Unknown Journal, 71(4), 832-836. https://doi.org/10.1172/JCI110836