Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Michael G Benatar, Hugh J. Willison, Angela Vincent

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalMuscle and Nerve
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Keywords

  • Ganglioside
  • GM
  • Gullain-Barre syndrome
  • Motor neuropathy
  • Voltage-gated sodium channel

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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