Abstract
Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-110 |
| Number of pages | 3 |
| Journal | Muscle and Nerve |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1999 |
| Externally published | Yes |
Keywords
- Ganglioside
- GM
- Gullain-Barre syndrome
- Motor neuropathy
- Voltage-gated sodium channel
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
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Benatar, M., Willison, H. J., & Vincent, A. (1999). Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. Muscle and Nerve, 22(1), 108-110. https://doi.org/10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I