Abstract
Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.
| Original language | English |
|---|---|
| Pages (from-to) | 108-110 |
| Number of pages | 3 |
| Journal | Muscle and Nerve |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1999 |
| Externally published | Yes |
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Keywords
- Ganglioside
- GM
- Gullain-Barre syndrome
- Motor neuropathy
- Voltage-gated sodium channel
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. / Benatar, Michael G; Willison, Hugh J.; Vincent, Angela.
In: Muscle and Nerve, Vol. 22, No. 1, 01.01.1999, p. 108-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune-mediated peripheral neuropathies and voltage-gated sodiums channels
AU - Benatar, Michael G
AU - Willison, Hugh J.
AU - Vincent, Angela
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.
AB - Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.
KW - Ganglioside
KW - GM
KW - Gullain-Barre syndrome
KW - Motor neuropathy
KW - Voltage-gated sodium channel
UR - http://www.scopus.com/inward/record.url?scp=0032889232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032889232&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I
DO - 10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I
M3 - Article
C2 - 9883864
AN - SCOPUS:0032889232
VL - 22
SP - 108
EP - 110
JO - Muscle and Nerve
JF - Muscle and Nerve
SN - 0148-639X
IS - 1
ER -