Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Michael G Benatar, Hugh J. Willison, Angela Vincent

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalMuscle and Nerve
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Voltage-Gated Sodium Channels
Peripheral Nervous System Diseases
G(M1) Ganglioside
Guillain-Barre Syndrome
Tetrodotoxin
Cell Line
Antibodies

Keywords

  • Ganglioside
  • GM
  • Gullain-Barre syndrome
  • Motor neuropathy
  • Voltage-gated sodium channel

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. / Benatar, Michael G; Willison, Hugh J.; Vincent, Angela.

In: Muscle and Nerve, Vol. 22, No. 1, 01.01.1999, p. 108-110.

Research output: Contribution to journalArticle

Benatar, Michael G ; Willison, Hugh J. ; Vincent, Angela. / Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. In: Muscle and Nerve. 1999 ; Vol. 22, No. 1. pp. 108-110.
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