Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Michael Benatar; Hugh J. Willison; Angela Vincent

doi:10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I

Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Michael Benatar, Hugh J. Willison, Angela Vincent

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Antibodies to GM₁ ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by ²²Na⁺ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM₁ ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.

Original language	English (US)
Pages (from-to)	108-110
Number of pages	3
Journal	Muscle and Nerve
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I
State	Published - 1999
Externally published	Yes

Keywords

Ganglioside
GM
Gullain-Barre syndrome
Motor neuropathy
Voltage-gated sodium channel

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Access to Document

10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I

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Cite this

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abstract = "Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.",

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AB - Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.

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