Abstract
Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barre syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cell.
Original language | English (US) |
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Pages (from-to) | 108-110 |
Number of pages | 3 |
Journal | Muscle and Nerve |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Ganglioside
- GM
- Gullain-Barre syndrome
- Motor neuropathy
- Voltage-gated sodium channel
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)