Immune mechanisms in inflammatory and degenerative eye disease

Victor L. Perez, Rachel R. Caspi

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


It has recently been recognized that pathology of age-associated degenerative eye diseases such as adult macular degeneration (AMD), glaucoma and diabetic retinopathy, have strong immunological underpinnings. Attempts have been made to extrapolate to age-related degenerative disease insights from inflammatory processes associated with non-infectious uveitis, but these have not yet been sufficiently informative. Here we review recent findings on the immune processes underlying uveitis and those that have been shown to contribute to AMD, discussing in this context parallels and differences between overt inflammation and para-inflammation in the eye. We propose that mechanisms associated with ocular immune privilege, in combination with paucity of age-related antigen(s) within the target tissue, dampen what could otherwise be overt inflammation and result in the para-inflammation that characterizes age-associated neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)354-363
Number of pages10
JournalTrends in Immunology
Issue number6
StatePublished - Jun 1 2015
Externally publishedYes


  • AMD
  • Degeneration
  • Inflammation
  • Parainflammation
  • Uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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