Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway

Melanie Ott, Stephane Emiliani, Carine Van Lint, Georges Herbein, Jennie Lovett, Narendra Chirmule, Thomas McCloskey, Savita Pahwa, Eric Verdin

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased in terleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors. Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28. IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL- 2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.

Original languageEnglish (US)
Pages (from-to)1481-1485
Number of pages5
JournalScience
Volume275
Issue number5305
DOIs
StatePublished - Mar 7 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Ott, M., Emiliani, S., Van Lint, C., Herbein, G., Lovett, J., Chirmule, N., McCloskey, T., Pahwa, S., & Verdin, E. (1997). Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science, 275(5305), 1481-1485. https://doi.org/10.1126/science.275.5305.1481