Immune defects in pediatric AIDS, their pathogenesis, and role of immunotherapy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Infection with the human immunodeficiency virus (HIV) results in a progressive immune deficiency involving many components of the immune system. The major target cells for infection are CD-4 antigen-bearing cells which include predominantly, but not exclusively, the helper T-cell subset and the monocyte-macrophage cell system. Defective cell-mediated immunity occurs in association with hypergammaglobulinemia, which is a common and early feature of HIV infection. Ability to mount specific antibody responses is often impaired and the in vitro B-cell differentiation responses to T-dependent and T-independent stimuli are depressed. Our investigations with HIV envelope proteins suggest that the viral proteins can exert both stimulatory and suppressive influences on B and T lymphocytes. In addition to the opportunistic infections, children with HIV disease frequently develop serious bacterial infections. Among the currently available immunotherapeutic strategies, iv immunoglobulin therapy has received the most attention as a means to provide antibody replacement in children with recurrent bacterial infections. This modality is likely to be most valuable as adjunctive therapy in treatment protocols directed at HIV and its disease complications.

Original languageEnglish
JournalCritical Care Medicine
Volume18
Issue number2 SUPPL.
StatePublished - Jan 1 1990
Externally publishedYes

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Immunotherapy
Acquired Immunodeficiency Syndrome
Virus Diseases
HIV
Pediatrics
Bacterial Infections
Human Immunodeficiency Virus env Gene Products
B-Lymphocytes
CD Antigens
Hypergammaglobulinemia
Passive Immunization
Opportunistic Infections
T-Lymphocyte Subsets
Viral Proteins
Clinical Protocols
Helper-Inducer T-Lymphocytes
Infection
Cellular Immunity
Antibody Formation
Monocytes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Immune defects in pediatric AIDS, their pathogenesis, and role of immunotherapy. / Pahwa, Savita G.

In: Critical Care Medicine, Vol. 18, No. 2 SUPPL., 01.01.1990.

Research output: Contribution to journalArticle

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