Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome

M. F. Falangola, B. G. Castro‐Filho, C. K. Petito

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We identified immune complex deposits in the choroid plexus of approximately 75% of patients with acquired immunodeficiency syndrome (AIDS) who had either normal brains or human immunodeficiency virus encephalitis. Since circulating immune complexes are common in AIDS patients, and since local choroid plexus pathology usually was absent, their likely origin is from the bloodstream. Choroid plexus deposits of immune complexes have been implicated in altering the function of this structure or in enhancing its vulnerability to infection. Therefore, immune complex deposition in the choroid plexus of AIDS patients may be responsible for some of the common alterations in the cerebrospinal fluid and for the frequency of opportunistic infections in this region.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalAnnals of neurology
Volume36
Issue number3
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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