Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome

M. F. Falangola, B. G. Castro-Filho, Carol Petito

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We identified immune complex deposits in the choroid plexus of approximately 75% of patients with acquired immunodeficiency syndrome (AIDS) who had either normal brains or human immunodeficiency virus encephalitis. Since circulating immune complexes are common in AIDS patients, and since local choroid plexus pathology usually was absent, their likely origin is from the bloodstream. Choroid plexus deposits of immune complexes have been implicated in altering the function of this structure or in enhancing its vulnerability to infection. Therefore, immune complex deposition in the choroid plexus of AIDS patients may be responsible for some of the common alterations in the cerebrospinal fluid and for the frequency of opportunistic infections in this region.

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalAnnals of Neurology
Volume36
Issue number3
StatePublished - Sep 1 1994

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Choroid Plexus
Antigen-Antibody Complex
Acquired Immunodeficiency Syndrome
Opportunistic Infections
Encephalitis
Cerebrospinal Fluid
HIV
Pathology
Brain
Infection

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Falangola, M. F., Castro-Filho, B. G., & Petito, C. (1994). Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome. Annals of Neurology, 36(3), 437-440.

Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome. / Falangola, M. F.; Castro-Filho, B. G.; Petito, Carol.

In: Annals of Neurology, Vol. 36, No. 3, 01.09.1994, p. 437-440.

Research output: Contribution to journalArticle

Falangola, MF, Castro-Filho, BG & Petito, C 1994, 'Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome', Annals of Neurology, vol. 36, no. 3, pp. 437-440.
Falangola, M. F. ; Castro-Filho, B. G. ; Petito, Carol. / Immune complex deposition in the choroid plexus of patients with acquired immunodeficiency syndrome. In: Annals of Neurology. 1994 ; Vol. 36, No. 3. pp. 437-440.
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