Abstract
The appropriate distribution of immune cells within the body is crucial for performance of the surveillance and effector functions of the immune system. Stress can significantly affect baseline leukocyte numbers as well as dynamic leukocyte distribution between different body compartments. Organs that are enriched with immune cells during stress may mount more robust immune responses, whereas those that are depleted may show suppressed immune function. It has been proposed that stress-induced changes in leukocyte trafficking may enhance immunoprotection during surgery, vaccination, or infection but may also exacerbate immunopathology during inflammatory (cardiovascular disease or gingivitis) or autoimmune (psoriasis, arthritis, or multiple sclerosis) diseases. © 2007
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Stress |
| Publisher | Elsevier Inc. |
| Pages | 449-455 |
| Number of pages | 7 |
| ISBN (Print) | 9780123739476 |
| DOIs | |
| State | Published - Dec 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Immune Cell Distribution, Effects of Stress on. / Dhabhar, Firdaus.
Encyclopedia of Stress. Elsevier Inc., 2010. p. 449-455.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Immune Cell Distribution, Effects of Stress on
AU - Dhabhar, Firdaus
PY - 2010/12/1
Y1 - 2010/12/1
N2 - The appropriate distribution of immune cells within the body is crucial for performance of the surveillance and effector functions of the immune system. Stress can significantly affect baseline leukocyte numbers as well as dynamic leukocyte distribution between different body compartments. Organs that are enriched with immune cells during stress may mount more robust immune responses, whereas those that are depleted may show suppressed immune function. It has been proposed that stress-induced changes in leukocyte trafficking may enhance immunoprotection during surgery, vaccination, or infection but may also exacerbate immunopathology during inflammatory (cardiovascular disease or gingivitis) or autoimmune (psoriasis, arthritis, or multiple sclerosis) diseases. © 2007
AB - The appropriate distribution of immune cells within the body is crucial for performance of the surveillance and effector functions of the immune system. Stress can significantly affect baseline leukocyte numbers as well as dynamic leukocyte distribution between different body compartments. Organs that are enriched with immune cells during stress may mount more robust immune responses, whereas those that are depleted may show suppressed immune function. It has been proposed that stress-induced changes in leukocyte trafficking may enhance immunoprotection during surgery, vaccination, or infection but may also exacerbate immunopathology during inflammatory (cardiovascular disease or gingivitis) or autoimmune (psoriasis, arthritis, or multiple sclerosis) diseases. © 2007
UR - http://www.scopus.com/inward/record.url?scp=84882922952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882922952&partnerID=8YFLogxK
U2 - 10.1016/B978-012373947-6.00217-8
DO - 10.1016/B978-012373947-6.00217-8
M3 - Chapter
AN - SCOPUS:84882922952
SN - 9780123739476
SP - 449
EP - 455
BT - Encyclopedia of Stress
PB - Elsevier Inc.
ER -