Immune Cell Distribution, Effects of Stress on

F. S. Dhabhar

doi:10.1016/B978-012373947-6.00217-8

Immune Cell Distribution, Effects of Stress on

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The appropriate distribution of immune cells within the body is crucial for performance of the surveillance and effector functions of the immune system. Stress can significantly affect baseline leukocyte numbers as well as dynamic leukocyte distribution between different body compartments. Organs that are enriched with immune cells during stress may mount more robust immune responses, whereas those that are depleted may show suppressed immune function. It has been proposed that stress-induced changes in leukocyte trafficking may enhance immunoprotection during surgery, vaccination, or infection but may also exacerbate immunopathology during inflammatory (cardiovascular disease or gingivitis) or autoimmune (psoriasis, arthritis, or multiple sclerosis) diseases. © 2007

Original language	English (US)
Title of host publication	Encyclopedia of Stress
Publisher	Elsevier Inc.
Pages	449-455
Number of pages	7
ISBN (Print)	9780123739476
DOIs	https://doi.org/10.1016/B978-012373947-6.00217-8
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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AB - The appropriate distribution of immune cells within the body is crucial for performance of the surveillance and effector functions of the immune system. Stress can significantly affect baseline leukocyte numbers as well as dynamic leukocyte distribution between different body compartments. Organs that are enriched with immune cells during stress may mount more robust immune responses, whereas those that are depleted may show suppressed immune function. It has been proposed that stress-induced changes in leukocyte trafficking may enhance immunoprotection during surgery, vaccination, or infection but may also exacerbate immunopathology during inflammatory (cardiovascular disease or gingivitis) or autoimmune (psoriasis, arthritis, or multiple sclerosis) diseases. © 2007

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PB - Elsevier Inc.

ER -

Immune Cell Distribution, Effects of Stress on

Abstract

ASJC Scopus subject areas

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