Abstract
Background: Persistent immune activation and microbial translocation associated with HIV infection likely place HIV-infected aging women at high risk of developing chronic age-related diseases. We investigated immune activation and microbial translocation in HIV-infected aging women in the post-menopausal ages. Methods: Twenty-seven post-menopausal women with HIV infection receiving antiretroviral treatment with documented viral suppression and 15 HIV-negative age-matched controls were enrolled. Levels of immune activation markers (T cell immune phenotype, sCD25, sCD14, sCD163), microbial translocation (LPS) and biomarkers of cardiovascular disease and impaired cognitive function (sVCAM-1, sICAM-1 and CXCL10) were evaluated. Results: T cell activation and exhaustion, monocyte/macrophage activation, and microbial translocation were significantly higher in HIV-infected women when compared to uninfected controls. Microbial translocation correlated with T cell and monocyte/macrophage activation. Biomarkers of cardiovascular disease and impaired cognition were elevated in women with HIV infection and correlated with immune activation. Conclusions: HIV-infected antiretroviral-treated aging women who achieved viral suppression are in a generalized status of immune activation and therefore are at an increased risk of age-associated end-organ diseases compared to uninfected age-matched controls.
| Original language | English |
|---|---|
| Article number | e63804 |
| Journal | PLoS One |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 28 2013 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Immune Activation in HIV-Infected Aging Women on Antiretrovirals-Implications for Age-Associated Comorbidities : A Cross-Sectional Pilot Study. / Alcaide, Maria L; Parmigiani, Anita; Pallikkuth, Suresh; Roach, Margaret; Freguja, Riccardo; Negra, Marina Della; Bolivar, Hector; Fischl, Margaret A; Pahwa, Savita G.
In: PLoS One, Vol. 8, No. 5, e63804, 28.05.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune Activation in HIV-Infected Aging Women on Antiretrovirals-Implications for Age-Associated Comorbidities
T2 - A Cross-Sectional Pilot Study
AU - Alcaide, Maria L
AU - Parmigiani, Anita
AU - Pallikkuth, Suresh
AU - Roach, Margaret
AU - Freguja, Riccardo
AU - Negra, Marina Della
AU - Bolivar, Hector
AU - Fischl, Margaret A
AU - Pahwa, Savita G
PY - 2013/5/28
Y1 - 2013/5/28
N2 - Background: Persistent immune activation and microbial translocation associated with HIV infection likely place HIV-infected aging women at high risk of developing chronic age-related diseases. We investigated immune activation and microbial translocation in HIV-infected aging women in the post-menopausal ages. Methods: Twenty-seven post-menopausal women with HIV infection receiving antiretroviral treatment with documented viral suppression and 15 HIV-negative age-matched controls were enrolled. Levels of immune activation markers (T cell immune phenotype, sCD25, sCD14, sCD163), microbial translocation (LPS) and biomarkers of cardiovascular disease and impaired cognitive function (sVCAM-1, sICAM-1 and CXCL10) were evaluated. Results: T cell activation and exhaustion, monocyte/macrophage activation, and microbial translocation were significantly higher in HIV-infected women when compared to uninfected controls. Microbial translocation correlated with T cell and monocyte/macrophage activation. Biomarkers of cardiovascular disease and impaired cognition were elevated in women with HIV infection and correlated with immune activation. Conclusions: HIV-infected antiretroviral-treated aging women who achieved viral suppression are in a generalized status of immune activation and therefore are at an increased risk of age-associated end-organ diseases compared to uninfected age-matched controls.
AB - Background: Persistent immune activation and microbial translocation associated with HIV infection likely place HIV-infected aging women at high risk of developing chronic age-related diseases. We investigated immune activation and microbial translocation in HIV-infected aging women in the post-menopausal ages. Methods: Twenty-seven post-menopausal women with HIV infection receiving antiretroviral treatment with documented viral suppression and 15 HIV-negative age-matched controls were enrolled. Levels of immune activation markers (T cell immune phenotype, sCD25, sCD14, sCD163), microbial translocation (LPS) and biomarkers of cardiovascular disease and impaired cognitive function (sVCAM-1, sICAM-1 and CXCL10) were evaluated. Results: T cell activation and exhaustion, monocyte/macrophage activation, and microbial translocation were significantly higher in HIV-infected women when compared to uninfected controls. Microbial translocation correlated with T cell and monocyte/macrophage activation. Biomarkers of cardiovascular disease and impaired cognition were elevated in women with HIV infection and correlated with immune activation. Conclusions: HIV-infected antiretroviral-treated aging women who achieved viral suppression are in a generalized status of immune activation and therefore are at an increased risk of age-associated end-organ diseases compared to uninfected age-matched controls.
UR - http://www.scopus.com/inward/record.url?scp=84878402244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878402244&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0063804
DO - 10.1371/journal.pone.0063804
M3 - Article
C2 - 23724003
AN - SCOPUS:84878402244
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 5
M1 - e63804
ER -