Immune Activation in HIV-Infected Aging Women on Antiretrovirals-Implications for Age-Associated Comorbidities: A Cross-Sectional Pilot Study

Maria L Alcaide, Anita Parmigiani, Suresh Pallikkuth, Margaret Roach, Riccardo Freguja, Marina Della Negra, Hector Bolivar, Margaret A Fischl, Savita G Pahwa

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Abstract

Background: Persistent immune activation and microbial translocation associated with HIV infection likely place HIV-infected aging women at high risk of developing chronic age-related diseases. We investigated immune activation and microbial translocation in HIV-infected aging women in the post-menopausal ages. Methods: Twenty-seven post-menopausal women with HIV infection receiving antiretroviral treatment with documented viral suppression and 15 HIV-negative age-matched controls were enrolled. Levels of immune activation markers (T cell immune phenotype, sCD25, sCD14, sCD163), microbial translocation (LPS) and biomarkers of cardiovascular disease and impaired cognitive function (sVCAM-1, sICAM-1 and CXCL10) were evaluated. Results: T cell activation and exhaustion, monocyte/macrophage activation, and microbial translocation were significantly higher in HIV-infected women when compared to uninfected controls. Microbial translocation correlated with T cell and monocyte/macrophage activation. Biomarkers of cardiovascular disease and impaired cognition were elevated in women with HIV infection and correlated with immune activation. Conclusions: HIV-infected antiretroviral-treated aging women who achieved viral suppression are in a generalized status of immune activation and therefore are at an increased risk of age-associated end-organ diseases compared to uninfected age-matched controls.

Original languageEnglish
Article numbere63804
JournalPLoS One
Volume8
Issue number5
DOIs
StatePublished - May 28 2013

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Comorbidity
Cross-Sectional Studies
Aging of materials
Chemical activation
HIV
HIV infections
HIV Infections
T-cells
macrophage activation
menopause
Macrophage Activation
T-lymphocytes
Biomarkers
T-Lymphocytes
cognition
monocytes
Cognition
cardiovascular diseases
Macrophages
Monocytes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Immune Activation in HIV-Infected Aging Women on Antiretrovirals-Implications for Age-Associated Comorbidities : A Cross-Sectional Pilot Study. / Alcaide, Maria L; Parmigiani, Anita; Pallikkuth, Suresh; Roach, Margaret; Freguja, Riccardo; Negra, Marina Della; Bolivar, Hector; Fischl, Margaret A; Pahwa, Savita G.

In: PLoS One, Vol. 8, No. 5, e63804, 28.05.2013.

Research output: Contribution to journalArticle

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AU - Roach, Margaret

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