We report four cases, ranging in age from 4 months to 17 years, who showed unexplained clinical and/or laboratory evidence of severe cellular immunodeficiency but lacked laboratory evidence of infection with human immunodeficiency virus types 1 or 2 (HIV-1, HIV-2). All four children were negative for HIV-1 antibody and p24 antigen. Additionally, three of four cases tested were negative for HIV-1 by viral culture, DNA polymerase chain reaction (PCR), and in vitro antibody production (IVAP) from cultured peripheral blood mononuclear cells (PBMC); and negative for HIV-2 by serology. None of these patients showed evidence of chronic infection with cytomegalovirus (CMV), Epstein-Barr virus (EBV), or any other identifiable infectious agent. Both parents of one child, and mothers of two others were negative for HIV-1. The cause for immune dysfunction in these children is unknown. It may have been caused by an infectious agent, or may be the result of a congenital immune defect which has not been characterized. There is also the possibility that the immune abnormalities may represent extreme variations of immune parameters in the population.
|Original language||English (US)|
|Number of pages||5|
|Journal||Pediatric AIDS and HIV Infection|
|State||Published - Jan 1 1994|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health