Immune abnormalities suggestive of pediatric AIDS without evidence of HIV- 1 or HIV-2

S. S. Bakshi, S. Sheikh, M. Paul, S. Tetali, X. P. Wang, S. Pahwa

Research output: Contribution to journalArticlepeer-review


We report four cases, ranging in age from 4 months to 17 years, who showed unexplained clinical and/or laboratory evidence of severe cellular immunodeficiency but lacked laboratory evidence of infection with human immunodeficiency virus types 1 or 2 (HIV-1, HIV-2). All four children were negative for HIV-1 antibody and p24 antigen. Additionally, three of four cases tested were negative for HIV-1 by viral culture, DNA polymerase chain reaction (PCR), and in vitro antibody production (IVAP) from cultured peripheral blood mononuclear cells (PBMC); and negative for HIV-2 by serology. None of these patients showed evidence of chronic infection with cytomegalovirus (CMV), Epstein-Barr virus (EBV), or any other identifiable infectious agent. Both parents of one child, and mothers of two others were negative for HIV-1. The cause for immune dysfunction in these children is unknown. It may have been caused by an infectious agent, or may be the result of a congenital immune defect which has not been characterized. There is also the possibility that the immune abnormalities may represent extreme variations of immune parameters in the population.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalPediatric AIDS and HIV Infection
Issue number3
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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