Immortalization in culture: Occurrence at a late stage in the progression of breast cancer

H. S. Smith, S. R. Wolman, S. H. Dairkee, M. C. Hancock, Marc E Lippman, A. Leff, A. J. Hackett

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Abstract

The properties in culture of 3 breast cancer effusion metastases, obtained over approximately 2 years from the same patient, were examined. Despite repeated attempts with cryopreserved cells, only the last specimen reproducibly exhibited immortality in culture; the first 2 specimens grew initially but failed to develop into cell lines. Each specimen was unique in morphology and growth properties, although karyotypic markers indicated a common origin. Aberrations of chromosomes 1 and 11 marked these near-diploid cells, and further structural alterations of chromosome 11 accompanied the transition of biological properties observed in the third specimen.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalJournal of the National Cancer Institute
Volume78
Issue number4
StatePublished - Jun 24 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smith, H. S., Wolman, S. R., Dairkee, S. H., Hancock, M. C., Lippman, M. E., Leff, A., & Hackett, A. J. (1987). Immortalization in culture: Occurrence at a late stage in the progression of breast cancer. Journal of the National Cancer Institute, 78(4), 611-615.