Immobilized ligands for cell and tissue interactions

J. A. Hubbell, P. D. Drumheller

Research output: Contribution to journalArticle

Abstract

The interaction of adhesion receptors with their protein ligands can be localized to small domains, called the cell-binding domain, on the surface of the protein. The receptor-binding activity of the cell-binding domain can be mimicked by short oligopeptides of the same or related sequence as that of the cell-binding domain. These oligopeptides have been incorporated into the surfaces of polymeric biomaterials, resulting in surfaces for the cells bear receptors directly.

Original languageEnglish
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1 1994
Externally publishedYes

Fingerprint

Immobilized Cells
Oligopeptides
Cell Communication
Ligands
Tissue
Cell Surface Receptors
Biocompatible Materials
Proteins
Membrane Proteins
Cells
Biomaterials
Adhesion
adhesion receptor

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Immobilized ligands for cell and tissue interactions. / Hubbell, J. A.; Drumheller, P. D.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 01.11.1994.

Research output: Contribution to journalArticle

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