Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion

S. P. Massia, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we investigate the nature of human foreskin fibroblast (HFF) adhesion in the absence of serum proteins to glass substrates containing covalently linked amines. Based on this study, it can be concluded that cell adhesion to diamine derivatized substrates, which are positively charged at neutral pH, is chondroitin sulfate proteoglycan-mediated in the HFF. The immobilized N, N-dimethyl ED provided a good functional mimic of the so-called heparin-binding domain of cell adhesion proteins for this cell type.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Place of PublicationAlgonquin, IL, United States
PublisherPubl by Soc for Biomaterials
Volume14
StatePublished - Jan 1 1991
Externally publishedYes
Event17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA
Duration: May 1 1991May 5 1991

Other

Other17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
CityScottsdale, AZ, USA
Period5/1/915/5/91

Fingerprint

Cell adhesion
Proteoglycans
Fibroblasts
Amines
Heparin
Chondroitin Sulfate Proteoglycans
Proteins
Diamines
Substrates
Blood Proteins
Adhesion
Glass
Sulfates

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Massia, S. P., & Hubbell, J. A. (1991). Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. In Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 14). Algonquin, IL, United States: Publ by Soc for Biomaterials.

Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. / Massia, S. P.; Hubbell, J. A.

Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 14 Algonquin, IL, United States : Publ by Soc for Biomaterials, 1991.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Massia, SP & Hubbell, JA 1991, Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. in Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 14, Publ by Soc for Biomaterials, Algonquin, IL, United States, 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA, 5/1/91.
Massia SP, Hubbell JA. Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. In Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 14. Algonquin, IL, United States: Publ by Soc for Biomaterials. 1991
Massia, S. P. ; Hubbell, J. A. / Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 14 Algonquin, IL, United States : Publ by Soc for Biomaterials, 1991.
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