Immmunological findings in neurological diseases associated with antibodies to HTLV-I

Activated lymphocytes in tropical spastic paraparesis

S. Jacobson, V. Zaninovic, C. Mora, P. Rodgers-Johnson, William Sheremata, C. J. Gibbs, D. C. Gajdusek, D. E. McFarlin

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.

Original languageEnglish
JournalAnnals of Neurology
Volume23
Issue numberSUPPL.
StatePublished - Jan 1 1988

Fingerprint

HTLV-I Antibodies
Tropical Spastic Paraparesis
Lymphocytes
Cellular Immunity
Viruses
T-Lymphocytes
Measles virus
Histocompatibility
Interleukin-2 Receptors
Spinal Cord Diseases
Retroviridae
Cerebrospinal Fluid
Leukocytes
Antibodies
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jacobson, S., Zaninovic, V., Mora, C., Rodgers-Johnson, P., Sheremata, W., Gibbs, C. J., ... McFarlin, D. E. (1988). Immmunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis. Annals of Neurology, 23(SUPPL.).

Immmunological findings in neurological diseases associated with antibodies to HTLV-I : Activated lymphocytes in tropical spastic paraparesis. / Jacobson, S.; Zaninovic, V.; Mora, C.; Rodgers-Johnson, P.; Sheremata, William; Gibbs, C. J.; Gajdusek, D. C.; McFarlin, D. E.

In: Annals of Neurology, Vol. 23, No. SUPPL., 01.01.1988.

Research output: Contribution to journalArticle

Jacobson, S, Zaninovic, V, Mora, C, Rodgers-Johnson, P, Sheremata, W, Gibbs, CJ, Gajdusek, DC & McFarlin, DE 1988, 'Immmunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis', Annals of Neurology, vol. 23, no. SUPPL..
Jacobson S, Zaninovic V, Mora C, Rodgers-Johnson P, Sheremata W, Gibbs CJ et al. Immmunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis. Annals of Neurology. 1988 Jan 1;23(SUPPL.).
Jacobson, S. ; Zaninovic, V. ; Mora, C. ; Rodgers-Johnson, P. ; Sheremata, William ; Gibbs, C. J. ; Gajdusek, D. C. ; McFarlin, D. E. / Immmunological findings in neurological diseases associated with antibodies to HTLV-I : Activated lymphocytes in tropical spastic paraparesis. In: Annals of Neurology. 1988 ; Vol. 23, No. SUPPL.
@article{e4cadae13ce64523b85b7f15d3366f75,
title = "Immmunological findings in neurological diseases associated with antibodies to HTLV-I: Activated lymphocytes in tropical spastic paraparesis",
abstract = "A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.",
author = "S. Jacobson and V. Zaninovic and C. Mora and P. Rodgers-Johnson and William Sheremata and Gibbs, {C. J.} and Gajdusek, {D. C.} and McFarlin, {D. E.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "23",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "SUPPL.",

}

TY - JOUR

T1 - Immmunological findings in neurological diseases associated with antibodies to HTLV-I

T2 - Activated lymphocytes in tropical spastic paraparesis

AU - Jacobson, S.

AU - Zaninovic, V.

AU - Mora, C.

AU - Rodgers-Johnson, P.

AU - Sheremata, William

AU - Gibbs, C. J.

AU - Gajdusek, D. C.

AU - McFarlin, D. E.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.

AB - A retrovirus involvement in the etiology of certain neurological diseases is currently an area of intense interest. Tropical spastic paraparesis and other chronic progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I; however, little is known about the cellular immune response. In the present study, activated T-lymphocytes were found in the peripheral blood of patients with this disorder. There were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules. In addition, a significantly elevated spontaneous lymphoproliferative response was demonstrated in all patients. This is consistent with the known in vitro effects of human T-lymphotropic virus type I. In one patient, a defect in the generation of measles virus-specific cytotoxic T cells was identified. These observations indicate abnormalities of the cellular immune response in tropical spastic paraparesis.

UR - http://www.scopus.com/inward/record.url?scp=0023750021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023750021&partnerID=8YFLogxK

M3 - Article

VL - 23

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - SUPPL.

ER -