Abstract
The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-28 |
| Number of pages | 8 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 31 |
| Issue number | 1 |
| State | Published - 1992 |
| Externally published | Yes |
Fingerprint
Keywords
- Imipramine
- Separation anxiety
- Tricyclics
ASJC Scopus subject areas
- Psychiatry and Mental health
- Developmental and Educational Psychology
- Pediatrics, Perinatology, and Child Health
Cite this
Imipramine treatment of children with separation anxiety disorder. / Klein, Rachel G.; Koplewicz, Harold S.; Kanner, Andres M.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 31, No. 1, 1992, p. 21-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Imipramine treatment of children with separation anxiety disorder
AU - Klein, Rachel G.
AU - Koplewicz, Harold S.
AU - Kanner, Andres M
PY - 1992
Y1 - 1992
N2 - The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.
AB - The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.
KW - Imipramine
KW - Separation anxiety
KW - Tricyclics
UR - http://www.scopus.com/inward/record.url?scp=0026605897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026605897&partnerID=8YFLogxK
M3 - Article
VL - 31
SP - 21
EP - 28
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 1
ER -