Abstract
The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:21–28.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-28 |
| Number of pages | 8 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
Keywords
- imipramine
- separation anxiety
- tricyclics
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Psychiatry and Mental health
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Cite this
KLEIN, RACHEL. G., KOPLEWICZ, HAROLD. S., & KANNER, ANDRES. (1992). Imipramine Treatment of Children with Separation Anxiety Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31(1), 21-28. https://doi.org/10.1097/00004583-199201000-00005