Imipramine Treatment of Children with Separation Anxiety Disorder

RACHEL G. KLEIN; HAROLD S. KOPLEWICZ; ANDRES KANNER

doi:10.1097/00004583-199201000-00005

Imipramine Treatment of Children with Separation Anxiety Disorder

RACHEL G. KLEIN, HAROLD S. KOPLEWICZ, ANDRES KANNER

Neurology

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:21–28.

Original language	English (US)
Pages (from-to)	21-28
Number of pages	8
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	31
Issue number	1
DOIs	https://doi.org/10.1097/00004583-199201000-00005
State	Published - 1992

Keywords

imipramine
separation anxiety
tricyclics

ASJC Scopus subject areas

Developmental and Educational Psychology
Psychiatry and Mental health

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10.1097/00004583-199201000-00005

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