Imipramine Treatment of Children with Separation Anxiety Disorder

RACHEL G. KLEIN, HAROLD S. KOPLEWICZ, ANDRES KANNER

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:21–28.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • imipramine
  • separation anxiety
  • tricyclics

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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