TY - JOUR
T1 - Imipramine Treatment of Children with Separation Anxiety Disorder
AU - KLEIN, RACHEL G.
AU - KOPLEWICZ, HAROLD S.
AU - KANNER, ANDRES
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:21–28.
AB - The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31, 1:21–28.
KW - imipramine
KW - separation anxiety
KW - tricyclics
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U2 - 10.1097/00004583-199201000-00005
DO - 10.1097/00004583-199201000-00005
M3 - Article
C2 - 1347039
AN - SCOPUS:0026605897
VL - 31
SP - 21
EP - 28
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 1
ER -