Imipramine treatment of children with separation anxiety disorder

Rachel G. Klein, Harold S. Koplewicz, Andres M Kanner

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The efficacy of imipramine was investigated in 20 children (ages 6 to 15) with separation anxiety disorder. Children were treated for a month with vigorous behavioral treatment. If they did not respond, they entered a double-blind, randomized, 6-week trial of imipramine or placebo. Of 45 children accepted, 21 (47%) entered the trial. About half the children improved with either treatment, and no superiority for imipramine was obtained. There was no instance of clinically significant EKG changes. This small study failed to replicate previous findings of imipramine efficacy in a similar, but larger, clinical population.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Separation Anxiety
Imipramine
Therapeutics
Electrocardiography
Placebos
Population

Keywords

  • Imipramine
  • Separation anxiety
  • Tricyclics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Pediatrics, Perinatology, and Child Health

Cite this

Imipramine treatment of children with separation anxiety disorder. / Klein, Rachel G.; Koplewicz, Harold S.; Kanner, Andres M.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 31, No. 1, 1992, p. 21-28.

Research output: Contribution to journalArticle

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