Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets

Alexander M. Efanov; Sergei V. Zaitsev; Per Olof Berggren; Hans Juergen Mest; Suad Efendic

doi:10.1006/bbrc.2001.4483

Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets

Alexander M. Efanov, Sergei V. Zaitsev, Per Olof Berggren, Hans Juergen Mest, Suad Efendic

Surgery

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Abstract

Imidazoline compound RX871024 and carbamylcholine (CCh) stimulate insulin secretion in isolated rat pancreatic islets. Combination of CCh and RX871024 induces a synergetic effect on insulin secretion. RX871024 and CCh produce twofold increases in diacylglycerol (DAG) concentration. The combination of two compounds has an additive effect on DAG concentration. Effects of RX871024 on insulin secretion and DAG concentration are not dependent on the presence of D609, an inhibitor of phosphatidylcholine-specific phospholipase C. It is concluded that as in case with CCh the increase in DAG concentration induced by imidazoline RX871024 contributes to the insulinotropic activity of the compound.

Original language	English (US)
Pages (from-to)	1070-1073
Number of pages	4
Journal	Biochemical and biophysical research communications
Volume	281
Issue number	5
DOIs	https://doi.org/10.1006/bbrc.2001.4483
State	Published - 2001

Keywords

DAG
Imidazoline
Insulin secretion
Pancreatic islets

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets",

abstract = "Imidazoline compound RX871024 and carbamylcholine (CCh) stimulate insulin secretion in isolated rat pancreatic islets. Combination of CCh and RX871024 induces a synergetic effect on insulin secretion. RX871024 and CCh produce twofold increases in diacylglycerol (DAG) concentration. The combination of two compounds has an additive effect on DAG concentration. Effects of RX871024 on insulin secretion and DAG concentration are not dependent on the presence of D609, an inhibitor of phosphatidylcholine-specific phospholipase C. It is concluded that as in case with CCh the increase in DAG concentration induced by imidazoline RX871024 contributes to the insulinotropic activity of the compound.",

keywords = "DAG, Imidazoline, Insulin secretion, Pancreatic islets",

author = "Efanov, {Alexander M.} and Zaitsev, {Sergei V.} and Berggren, {Per Olof} and Mest, {Hans Juergen} and Suad Efendic",

note = "Funding Information: This study was supported by Eli Lilly & Company, the Swedish Medical Research Council (72X-00034, 72X-09890, 72XS-12708), the Royal Swedish Academy of Sciences, the Swedish Diabetes Association, the Nordic Insulin Foundation Committee, Nordic Insulin Foundation, Berth von Kantzows Foundation, Novo Nordisk Foundation, and Funds of the Karolinska Institutet.",

year = "2001",

doi = "10.1006/bbrc.2001.4483",

language = "English (US)",

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pages = "1070--1073",

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T1 - Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets

AU - Efanov, Alexander M.

AU - Zaitsev, Sergei V.

AU - Berggren, Per Olof

AU - Mest, Hans Juergen

AU - Efendic, Suad

N1 - Funding Information: This study was supported by Eli Lilly & Company, the Swedish Medical Research Council (72X-00034, 72X-09890, 72XS-12708), the Royal Swedish Academy of Sciences, the Swedish Diabetes Association, the Nordic Insulin Foundation Committee, Nordic Insulin Foundation, Berth von Kantzows Foundation, Novo Nordisk Foundation, and Funds of the Karolinska Institutet.

PY - 2001

Y1 - 2001

N2 - Imidazoline compound RX871024 and carbamylcholine (CCh) stimulate insulin secretion in isolated rat pancreatic islets. Combination of CCh and RX871024 induces a synergetic effect on insulin secretion. RX871024 and CCh produce twofold increases in diacylglycerol (DAG) concentration. The combination of two compounds has an additive effect on DAG concentration. Effects of RX871024 on insulin secretion and DAG concentration are not dependent on the presence of D609, an inhibitor of phosphatidylcholine-specific phospholipase C. It is concluded that as in case with CCh the increase in DAG concentration induced by imidazoline RX871024 contributes to the insulinotropic activity of the compound.

AB - Imidazoline compound RX871024 and carbamylcholine (CCh) stimulate insulin secretion in isolated rat pancreatic islets. Combination of CCh and RX871024 induces a synergetic effect on insulin secretion. RX871024 and CCh produce twofold increases in diacylglycerol (DAG) concentration. The combination of two compounds has an additive effect on DAG concentration. Effects of RX871024 on insulin secretion and DAG concentration are not dependent on the presence of D609, an inhibitor of phosphatidylcholine-specific phospholipase C. It is concluded that as in case with CCh the increase in DAG concentration induced by imidazoline RX871024 contributes to the insulinotropic activity of the compound.

KW - DAG

KW - Imidazoline

KW - Insulin secretion

KW - Pancreatic islets

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ER -

Imidazoline RX871024 raises diacylglycerol levels in rat pancreatic islets

Abstract

Keywords

ASJC Scopus subject areas

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