Imaging of visceral adipose tissue: An emerging diagnostic tool and therapeutic target

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Several lines of evidence support the contention that excess visceral fat plays a significant role in the development of an unfavourable metabolic and cardiovascular risk profile. Hence, estimation of visceral adipose tissue (VAT), that is, the fat surrounding the internal organs might be important for cardiovascular risk stratification. Classically, anthropometric measures have been employed to assess body fat distribution for risk assessment. But more recently, imaging methods for visceral fat quantitation have become a focus of attention particularly in a clinical research setting. Several imaging methods have evolved for estimation of VAT mass. Among these, magnetic resonance imaging (MRI) is fairly well established, but ultrasound and magnetic resonance spectroscopy (MRS) are also emerging as useful methods for quantitation of VAT and fat tissue content in vivo. Ultrasound is the most cost-effective and a convenient. imaging tool whereas MRS is still in its infancy but it is highly promising because of its high sensitivity and specificity. There is a compelling need to quantify VAT not only for diagnostic purpose, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to with adipose tissue. For example, changes in regional fat distribution can be used to estimate drugs effectiveness and their mechanism of action. Therefore, in this review I shall present briefly latest and main imaging techniques to detect the visceral adiposity, including the new ultrasound measurements of different visceral adipose tissue compartments. Some visceral adipose tissues which are not traditionally assessed, such as intraperationeal, mediastinal and the relatively small depots, such as epicardial adipose tissue have also been recently studied and are now proposed as new markers of visceral adiposity.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalCurrent Drug Targets - Cardiovascular and Haematological Disorders
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Fingerprint

Intra-Abdominal Fat
Fats
Adiposity
Therapeutics
Adipose Tissue
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations
Body Fat Distribution
Weight Loss
Magnetic Resonance Imaging
Costs and Cost Analysis
Sensitivity and Specificity
Research

Keywords

  • Abdominal ultrasound
  • Adipose tissue imaging
  • Echocardiography
  • Epicardial adipose tissue
  • Magnetic resonance Spectroscopy
  • Visceral adiposity

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Hematology
  • Pharmacology

Cite this

@article{a41f4a920ca34d9f862b8bc706f68ef8,
title = "Imaging of visceral adipose tissue: An emerging diagnostic tool and therapeutic target",
abstract = "Several lines of evidence support the contention that excess visceral fat plays a significant role in the development of an unfavourable metabolic and cardiovascular risk profile. Hence, estimation of visceral adipose tissue (VAT), that is, the fat surrounding the internal organs might be important for cardiovascular risk stratification. Classically, anthropometric measures have been employed to assess body fat distribution for risk assessment. But more recently, imaging methods for visceral fat quantitation have become a focus of attention particularly in a clinical research setting. Several imaging methods have evolved for estimation of VAT mass. Among these, magnetic resonance imaging (MRI) is fairly well established, but ultrasound and magnetic resonance spectroscopy (MRS) are also emerging as useful methods for quantitation of VAT and fat tissue content in vivo. Ultrasound is the most cost-effective and a convenient. imaging tool whereas MRS is still in its infancy but it is highly promising because of its high sensitivity and specificity. There is a compelling need to quantify VAT not only for diagnostic purpose, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to with adipose tissue. For example, changes in regional fat distribution can be used to estimate drugs effectiveness and their mechanism of action. Therefore, in this review I shall present briefly latest and main imaging techniques to detect the visceral adiposity, including the new ultrasound measurements of different visceral adipose tissue compartments. Some visceral adipose tissues which are not traditionally assessed, such as intraperationeal, mediastinal and the relatively small depots, such as epicardial adipose tissue have also been recently studied and are now proposed as new markers of visceral adiposity.",
keywords = "Abdominal ultrasound, Adipose tissue imaging, Echocardiography, Epicardial adipose tissue, Magnetic resonance Spectroscopy, Visceral adiposity",
author = "Gianluca Iacobellis",
year = "2005",
month = "8",
day = "1",
doi = "10.2174/1568006054553408",
language = "English",
volume = "5",
pages = "345--353",
journal = "Cardiovascular and Hematological Disorders - Drug Targets",
issn = "1871-529X",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Imaging of visceral adipose tissue

T2 - An emerging diagnostic tool and therapeutic target

AU - Iacobellis, Gianluca

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Several lines of evidence support the contention that excess visceral fat plays a significant role in the development of an unfavourable metabolic and cardiovascular risk profile. Hence, estimation of visceral adipose tissue (VAT), that is, the fat surrounding the internal organs might be important for cardiovascular risk stratification. Classically, anthropometric measures have been employed to assess body fat distribution for risk assessment. But more recently, imaging methods for visceral fat quantitation have become a focus of attention particularly in a clinical research setting. Several imaging methods have evolved for estimation of VAT mass. Among these, magnetic resonance imaging (MRI) is fairly well established, but ultrasound and magnetic resonance spectroscopy (MRS) are also emerging as useful methods for quantitation of VAT and fat tissue content in vivo. Ultrasound is the most cost-effective and a convenient. imaging tool whereas MRS is still in its infancy but it is highly promising because of its high sensitivity and specificity. There is a compelling need to quantify VAT not only for diagnostic purpose, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to with adipose tissue. For example, changes in regional fat distribution can be used to estimate drugs effectiveness and their mechanism of action. Therefore, in this review I shall present briefly latest and main imaging techniques to detect the visceral adiposity, including the new ultrasound measurements of different visceral adipose tissue compartments. Some visceral adipose tissues which are not traditionally assessed, such as intraperationeal, mediastinal and the relatively small depots, such as epicardial adipose tissue have also been recently studied and are now proposed as new markers of visceral adiposity.

AB - Several lines of evidence support the contention that excess visceral fat plays a significant role in the development of an unfavourable metabolic and cardiovascular risk profile. Hence, estimation of visceral adipose tissue (VAT), that is, the fat surrounding the internal organs might be important for cardiovascular risk stratification. Classically, anthropometric measures have been employed to assess body fat distribution for risk assessment. But more recently, imaging methods for visceral fat quantitation have become a focus of attention particularly in a clinical research setting. Several imaging methods have evolved for estimation of VAT mass. Among these, magnetic resonance imaging (MRI) is fairly well established, but ultrasound and magnetic resonance spectroscopy (MRS) are also emerging as useful methods for quantitation of VAT and fat tissue content in vivo. Ultrasound is the most cost-effective and a convenient. imaging tool whereas MRS is still in its infancy but it is highly promising because of its high sensitivity and specificity. There is a compelling need to quantify VAT not only for diagnostic purpose, but also for therapeutic interventions with weight reduction drugs or pharmaceuticals targeted to with adipose tissue. For example, changes in regional fat distribution can be used to estimate drugs effectiveness and their mechanism of action. Therefore, in this review I shall present briefly latest and main imaging techniques to detect the visceral adiposity, including the new ultrasound measurements of different visceral adipose tissue compartments. Some visceral adipose tissues which are not traditionally assessed, such as intraperationeal, mediastinal and the relatively small depots, such as epicardial adipose tissue have also been recently studied and are now proposed as new markers of visceral adiposity.

KW - Abdominal ultrasound

KW - Adipose tissue imaging

KW - Echocardiography

KW - Epicardial adipose tissue

KW - Magnetic resonance Spectroscopy

KW - Visceral adiposity

UR - http://www.scopus.com/inward/record.url?scp=23744458765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744458765&partnerID=8YFLogxK

U2 - 10.2174/1568006054553408

DO - 10.2174/1568006054553408

M3 - Article

C2 - 16101567

AN - SCOPUS:23744458765

VL - 5

SP - 345

EP - 353

JO - Cardiovascular and Hematological Disorders - Drug Targets

JF - Cardiovascular and Hematological Disorders - Drug Targets

SN - 1871-529X

IS - 4

ER -