Imaging of eye tumor in the mouse model of retinoblastoma with spectral-domain optical coherence tomography

Jiao Shuliang, Marco Ruggeri, Hassan Wehbe, Giovanni Gregory, Maria E. Jockovich, Abigail Hackam, Carmen A. Puliafito

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Noninvasive in vivo examination of the rodent retina without sacrificing the animal is the key to being able to perform longitudinal studies. This allows the monitoring of disease progression and the response to therapies through its entire course in individual animal. A high-speed high resolution three-dimensional spectral-domain OCT is built for non-contact in vivo imaging of rodent retina. The system is able to acquire high quality 3D images of the rodent retina in 2.7 seconds (total imaging time is ∼5 minutes). The system was tested on mice with normal retina (B6/SJLF2), mouse model for photoreceptor degeneration (Rho-/-), and mouse model for retinoblastoma (LH BETATAG)- For the first time to our knowledge, 3D image of the tumor in retinoblastoma mouse model was successfully imaged in vivo. By segmenting the tumor boundaries in each frame of the OCT image the volume of the tumor was successfully calculated.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XVII
DOIs
StatePublished - Aug 31 2007
EventOphthalmic Technologies XVII - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6426
ISSN (Print)1605-7422

Other

OtherOphthalmic Technologies XVII
CountryUnited States
CitySan Jose, CA
Period1/20/071/23/07

Keywords

  • Mouse
  • Optical coherence tomography
  • Rat
  • Retina
  • Tumor

ASJC Scopus subject areas

  • Engineering(all)

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    Shuliang, J., Ruggeri, M., Wehbe, H., Gregory, G., Jockovich, M. E., Hackam, A., & Puliafito, C. A. (2007). Imaging of eye tumor in the mouse model of retinoblastoma with spectral-domain optical coherence tomography. In Ophthalmic Technologies XVII [64260D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6426). https://doi.org/10.1117/12.700338