Abstract
The diagnosis of hepatocellular carcinoma (HCC) is based on imaging examinations in combination with clinical and laboratory findings. Despite technological advances, imaging cirrhotic patients remains a challenging issue because nonmalignant hepatocellular lesions, such as dysplastic nodules, mimic a small HCC. One of the key pathologic factors for differential diagnosis that is reflected in imaging appearances is the vascular supply to the lesion. It is accepted that imaging techniques may establish the diagnosis of HCC in nodules larger than 2 cm showing characteristic arterial hypervascularization. In lesions ranging from 1 to 2 cm, biopsy is still recommended, although a negative response can never be used to rule out malignancy completely. Although ultrasonography is widely accepted for HCC surveillance, spiral computed tomography (CT) or dynamic magnetic resonance imaging is required for diagnostic confirmation and intrahepatic tumor staging. These examinations have replaced invasive procedures, such as lipiodol CT, but remain relatively insensitive for the detection of tiny HCC lesions and tumor vascular invasion into peripheral portal vein branches.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 162-170 |
| Number of pages | 9 |
| Journal | Seminars in Liver Disease |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 2005 |
| Externally published | Yes |
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Keywords
- Computed tomography
- Magnetic resonance imaging
- Percutaneous biopsy
- Ultrasonography
ASJC Scopus subject areas
- Hepatology
Cite this
Imaging diagnosis. / Lencioni, Riccardo; Cioni, Dania; Della Pina, Clotilde; Crocetti, Laura; Bartolozzi, Carlo.
In: Seminars in Liver Disease, Vol. 25, No. 2, 05.2005, p. 162-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Imaging diagnosis
AU - Lencioni, Riccardo
AU - Cioni, Dania
AU - Della Pina, Clotilde
AU - Crocetti, Laura
AU - Bartolozzi, Carlo
PY - 2005/5
Y1 - 2005/5
N2 - The diagnosis of hepatocellular carcinoma (HCC) is based on imaging examinations in combination with clinical and laboratory findings. Despite technological advances, imaging cirrhotic patients remains a challenging issue because nonmalignant hepatocellular lesions, such as dysplastic nodules, mimic a small HCC. One of the key pathologic factors for differential diagnosis that is reflected in imaging appearances is the vascular supply to the lesion. It is accepted that imaging techniques may establish the diagnosis of HCC in nodules larger than 2 cm showing characteristic arterial hypervascularization. In lesions ranging from 1 to 2 cm, biopsy is still recommended, although a negative response can never be used to rule out malignancy completely. Although ultrasonography is widely accepted for HCC surveillance, spiral computed tomography (CT) or dynamic magnetic resonance imaging is required for diagnostic confirmation and intrahepatic tumor staging. These examinations have replaced invasive procedures, such as lipiodol CT, but remain relatively insensitive for the detection of tiny HCC lesions and tumor vascular invasion into peripheral portal vein branches.
AB - The diagnosis of hepatocellular carcinoma (HCC) is based on imaging examinations in combination with clinical and laboratory findings. Despite technological advances, imaging cirrhotic patients remains a challenging issue because nonmalignant hepatocellular lesions, such as dysplastic nodules, mimic a small HCC. One of the key pathologic factors for differential diagnosis that is reflected in imaging appearances is the vascular supply to the lesion. It is accepted that imaging techniques may establish the diagnosis of HCC in nodules larger than 2 cm showing characteristic arterial hypervascularization. In lesions ranging from 1 to 2 cm, biopsy is still recommended, although a negative response can never be used to rule out malignancy completely. Although ultrasonography is widely accepted for HCC surveillance, spiral computed tomography (CT) or dynamic magnetic resonance imaging is required for diagnostic confirmation and intrahepatic tumor staging. These examinations have replaced invasive procedures, such as lipiodol CT, but remain relatively insensitive for the detection of tiny HCC lesions and tumor vascular invasion into peripheral portal vein branches.
KW - Computed tomography
KW - Magnetic resonance imaging
KW - Percutaneous biopsy
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=20344383741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20344383741&partnerID=8YFLogxK
U2 - 10.1055/s-2005-871196
DO - 10.1055/s-2005-871196
M3 - Article
VL - 25
SP - 162
EP - 170
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 2
ER -