TY - JOUR
T1 - IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor
AU - TANIGUCHI, TADATSUGU
AU - MIYAZAKI, TADAAKI
AU - MINAMI, YASUHIRO
AU - KAWAHARA, ATSUO
AU - FUJII, HODAKA
AU - NAKAGAWA, YOKO
AU - HATAKEYAMA, MASANORI
AU - LIU, ZHAO‐JUN ‐J
PY - 1995/9
Y1 - 1995/9
N2 - The IL-2 receptor (IL-2R) consists of three subunits, the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, IL-9, IL-13, and IL-15. The IL-2-induced proliferative signals emanate from the cytoplasmic domains of IL-2Rβ and IL-2Rγ, but the nature and function of the signaling molecules that transmit these signals are not fully understood. Here we summarize our current understanding of the mechanisms by which IL-2R transmit signals by using multiple protein kinases. In fact, at least four protein tyrosine kinases (PTKs) are physically associated with IL-2R: p56(lck) (and its members), Syk PTK, and the Janus kinases, Jak1 and Jak3. cDNA expression studies revealed that the activation of these PTKs is critical for IL-2-induced proliferative signal transmission. Our findings indicate that a unique property of the IL-2R cytoplasmic domains is to recruit a variety of signaling molecules, which may suggest a mechanism by which these PTKs and other signaling molecules function in concert.
AB - The IL-2 receptor (IL-2R) consists of three subunits, the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, IL-9, IL-13, and IL-15. The IL-2-induced proliferative signals emanate from the cytoplasmic domains of IL-2Rβ and IL-2Rγ, but the nature and function of the signaling molecules that transmit these signals are not fully understood. Here we summarize our current understanding of the mechanisms by which IL-2R transmit signals by using multiple protein kinases. In fact, at least four protein tyrosine kinases (PTKs) are physically associated with IL-2R: p56(lck) (and its members), Syk PTK, and the Janus kinases, Jak1 and Jak3. cDNA expression studies revealed that the activation of these PTKs is critical for IL-2-induced proliferative signal transmission. Our findings indicate that a unique property of the IL-2R cytoplasmic domains is to recruit a variety of signaling molecules, which may suggest a mechanism by which these PTKs and other signaling molecules function in concert.
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U2 - 10.1111/j.1749-6632.1995.tb26671.x
DO - 10.1111/j.1749-6632.1995.tb26671.x
M3 - Article
C2 - 7486666
AN - SCOPUS:0029551216
VL - 766
SP - 235
EP - 244
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -