IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor

TADATSUGU TANIGUCHI, TADAAKI MIYAZAKI, YASUHIRO MINAMI, ATSUO KAWAHARA, HODAKA FUJII, YOKO NAKAGAWA, MASANORI HATAKEYAMA, ZHAO‐JUN ‐J LIU

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The IL-2 receptor (IL-2R) consists of three subunits, the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, IL-9, IL-13, and IL-15. The IL-2-induced proliferative signals emanate from the cytoplasmic domains of IL-2Rβ and IL-2Rγ, but the nature and function of the signaling molecules that transmit these signals are not fully understood. Here we summarize our current understanding of the mechanisms by which IL-2R transmit signals by using multiple protein kinases. In fact, at least four protein tyrosine kinases (PTKs) are physically associated with IL-2R: p56(lck) (and its members), Syk PTK, and the Janus kinases, Jak1 and Jak3. cDNA expression studies revealed that the activation of these PTKs is critical for IL-2-induced proliferative signal transmission. Our findings indicate that a unique property of the IL-2R cytoplasmic domains is to recruit a variety of signaling molecules, which may suggest a mechanism by which these PTKs and other signaling molecules function in concert.

Original languageEnglish (US)
Pages (from-to)235-244
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume766
Issue number1
DOIs
StatePublished - Sep 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor'. Together they form a unique fingerprint.

  • Cite this

    TANIGUCHI, TADATSUGU., MIYAZAKI, TADAAKI., MINAMI, YASUHIRO., KAWAHARA, ATSUO., FUJII, HODAKA., NAKAGAWA, YOKO., HATAKEYAMA, MASANORI., & LIU, ZHAOJUN. J. (1995). IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor. Annals of the New York Academy of Sciences, 766(1), 235-244. https://doi.org/10.1111/j.1749-6632.1995.tb26671.x