IL-7–dependent STAT1 activation limits homeostatic CD4+ T cell expansion

Cecile Le Saout, Megan A. Luckey, Alejandro V. Villarino, Mindy Smith, Rebecca B. Hasley, Timothy G. Myers, Hiromi Imamichi, Jung Hyun Park, John J. O’Shea, H. Clifford Lane, Marta Catalfamo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

IL-7 regulates homeostatic mechanisms that maintain the overall size of the T cell pool throughout life. We show that, under steady-state conditions, IL-7 signaling is principally mediated by activation of signal transducers and activators of transcription 5 (STAT5). In contrast, under lymphopenic conditions, there is a modulation of STAT1 expression resulting in an IL-7–dependent STAT1 and STAT5 activation. Consequently, the IL-7–induced transcriptome is altered with enrichment of IFN-stimulated genes (ISGs). Moreover, STAT1 overexpression was associated with reduced survival in CD4+ T cells undergoing lymphopenia-induced proliferation (LIP). We propose a model in which T cells undergoing LIP upregulate STAT1 protein, “switching on” an alternate IL-7–dependent program. This mechanism could be a physiological process to regulate the expansion and size of the CD4+ T cell pool. During HIV infection, the virus could exploit this pathway, leading to the homeostatic dysregulation of the T cell pools observed in these patients.

Original languageEnglish (US)
Article numbere96228
JournalJCI Insight
Volume2
Issue number22
DOIs
StatePublished - Nov 16 2017
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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