IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway

Yong Woo Lee, Hartmut Kühn, Bernhard Hennig, Michal Toborek

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The present study was designed to investigate the hypothesis that interleukin-4 (IL-4) can induce apoptosis of human endothelial cells and to study regulatory pathways of this process. Indeed, DNA ladder assay and flow cytometry study showed that IL-4 can induce apoptosis of endothelial cells in a time- and dose-dependent manner. In addition, IL-4 markedly increased activity of caspase-3, and inhibition of this enzyme suppressed IL-4-induced apoptosis in a dose-dependent manner. These results provide the first evidence that IL-4 can induce apoptosis of human endothelial cells. In addition, the data indicate that the caspase-3-dependent pathway is critically involved in this process.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalFEBS letters
Volume485
Issue number2-3
DOIs
StatePublished - Nov 24 2000
Externally publishedYes

Keywords

  • Apoptosis
  • Atherosclerosis
  • Caspase-3
  • Human endothelial cell
  • Interleukin-4

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway'. Together they form a unique fingerprint.

  • Cite this