IL-2 receptor signaling is essential for the development of Klrg1 + terminally differentiated T regulatory cells

Guoyan Cheng, Xiaomei Yuan, Matthew S. Tsai, Eckhard R. Podack, Aixin Yu, Thomas Malek

Research output: Contribution to journalArticle

56 Scopus citations


Thymic-derived natural T regulatory cells (Tregs) are characterized by functional and phenotypic heterogeneity. Recently, a small fraction of peripheral Tregs has been shown to express Klrg1, but it remains unclear as to what extent Klrg1 defines a unique Treg subset. In this study, we show that Klrg1 + Tregs represent a terminally differentiated Treg subset derived from Klrg1 - Tregs. This subset is a recent Ag-responsive and highly activated short-lived Treg population that expresses enhanced levels of Treg suppressive molecules and that preferentially resides within mucosal tissues. The development of Klrg1 + Tregs also requires extensive IL-2R signaling. This activity represents a distinct function for IL-2, independent from its contribution to Treg homeostasis and competitive fitness. These and other properties are analogous to terminally differentiated short-lived CD8 + T effector cells. Our findings suggest that an important pathway driving Ag-activated conventional T lymphocytes also operates for Tregs.

Original languageEnglish
Pages (from-to)1780-1791
Number of pages12
JournalJournal of Immunology
Issue number4
StatePublished - Aug 15 2012


ASJC Scopus subject areas

  • Immunology

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