Abstract
Introduction: Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4 + Foxp3low CD25neg T cells develop, and these cells fail to suppress autoreactive T cells in the periphery. Discussion: IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the thymus during neonatal life, IL-2 is responsible for rapid amplification of the number of Treg cells in peripheral lymph nodes to insure suppression of autoreactive T cells that escape negative selection, thereby maintaining tolerance. The homeostasis of Treg cells in mature immunocompetent mice also depends on IL-2. However, there is an alternative mechanism for Treg cells homeostasis that may represent a minor IL-2-independent pathway or the consequence of weak and very transient IL-2R signaling. Conclusion: Thus, IL-2 provides importance signals for Treg cell development and for their homeostasis in peripheral immune tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 635-639 |
| Number of pages | 5 |
| Journal | Journal of Clinical Immunology |
| Volume | 28 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2008 |
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Keywords
- Foxp3
- IL-2R
- IL-7R
- Survival
- Thymic development
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
IL-2 family of cytokines in T regulatory cell development and homeostasis. / Malek, Thomas; Yu, Aixin; Zhu, Linjian; Matsutani, Takaji; Adeegbe, Dennis; Bayer, Allison L.
In: Journal of Clinical Immunology, Vol. 28, No. 6, 01.11.2008, p. 635-639.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IL-2 family of cytokines in T regulatory cell development and homeostasis
AU - Malek, Thomas
AU - Yu, Aixin
AU - Zhu, Linjian
AU - Matsutani, Takaji
AU - Adeegbe, Dennis
AU - Bayer, Allison L
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Introduction: Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4 + Foxp3low CD25neg T cells develop, and these cells fail to suppress autoreactive T cells in the periphery. Discussion: IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the thymus during neonatal life, IL-2 is responsible for rapid amplification of the number of Treg cells in peripheral lymph nodes to insure suppression of autoreactive T cells that escape negative selection, thereby maintaining tolerance. The homeostasis of Treg cells in mature immunocompetent mice also depends on IL-2. However, there is an alternative mechanism for Treg cells homeostasis that may represent a minor IL-2-independent pathway or the consequence of weak and very transient IL-2R signaling. Conclusion: Thus, IL-2 provides importance signals for Treg cell development and for their homeostasis in peripheral immune tissues.
AB - Introduction: Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4 + Foxp3low CD25neg T cells develop, and these cells fail to suppress autoreactive T cells in the periphery. Discussion: IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the thymus during neonatal life, IL-2 is responsible for rapid amplification of the number of Treg cells in peripheral lymph nodes to insure suppression of autoreactive T cells that escape negative selection, thereby maintaining tolerance. The homeostasis of Treg cells in mature immunocompetent mice also depends on IL-2. However, there is an alternative mechanism for Treg cells homeostasis that may represent a minor IL-2-independent pathway or the consequence of weak and very transient IL-2R signaling. Conclusion: Thus, IL-2 provides importance signals for Treg cell development and for their homeostasis in peripheral immune tissues.
KW - Foxp3
KW - IL-2R
KW - IL-7R
KW - Survival
KW - Thymic development
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UR - http://www.scopus.com/inward/citedby.url?scp=56649095904&partnerID=8YFLogxK
U2 - 10.1007/s10875-008-9235-y
DO - 10.1007/s10875-008-9235-y
M3 - Article
VL - 28
SP - 635
EP - 639
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 6
ER -