IL-15/IL-15 receptor biology

A guided tour through an expanding universe

Vadim Budagian, Elena Bulanova, Ralf Paus, Silvia Bulfone-Paus

Research output: Contribution to journalReview article

246 Citations (Scopus)

Abstract

The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.

Original languageEnglish (US)
Pages (from-to)259-280
Number of pages22
JournalCytokine and Growth Factor Reviews
Volume17
Issue number4
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Interleukin-15 Receptors
Interleukin-15
T-cells
Natural Killer T-Cells
Health Services Needs and Demand
Natural Killer Cells
Interleukin-2
Chemical activation
Cells
Cytokines
T-Lymphocytes
Therapeutics

Keywords

  • Apoptosis
  • IL-15
  • IL-15 receptor α
  • Signal transduction
  • trans-Presentation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

IL-15/IL-15 receptor biology : A guided tour through an expanding universe. / Budagian, Vadim; Bulanova, Elena; Paus, Ralf; Bulfone-Paus, Silvia.

In: Cytokine and Growth Factor Reviews, Vol. 17, No. 4, 01.08.2006, p. 259-280.

Research output: Contribution to journalReview article

Budagian, Vadim ; Bulanova, Elena ; Paus, Ralf ; Bulfone-Paus, Silvia. / IL-15/IL-15 receptor biology : A guided tour through an expanding universe. In: Cytokine and Growth Factor Reviews. 2006 ; Vol. 17, No. 4. pp. 259-280.
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