IL-15/IL-15 receptor biology: A guided tour through an expanding universe

Vadim Budagian, Elena Bulanova, Ralf Paus, Silvia Bulfone-Paus

Research output: Contribution to journalReview articlepeer-review

268 Scopus citations


The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.

Original languageEnglish (US)
Pages (from-to)259-280
Number of pages22
JournalCytokine and Growth Factor Reviews
Issue number4
StatePublished - Aug 2006
Externally publishedYes


  • Apoptosis
  • IL-15
  • IL-15 receptor α
  • Signal transduction
  • trans-Presentation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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