IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens

Eugenio Gallo, Shoshana Katzman, Alejandro V. Villarino

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In helper T cells, IL-13 is traditionally considered a Th2-type cytokine that is coexpressed with IL-4. Using mouse models of immunization and autoimmunity, we demonstrate that IL-13 is frequently uncoupled from IL-4, and that it can be produced by both IFN-γ+ Th1 cells and IL-17+ Th17 cells. We report that these IL-13-producing Th1 and Th17 cells are distinct from classical IL-4+ Th2 cells and that they are relatively common, appearing in the context of both protective and pathogenic T-cell responses. We also demonstrate that IL-13 and Th2-type cytokines can have important consequences in Th1- and Th17-dominated settings, such as lymphopenia-induced autoimmune disease, where they can be either pro- or anti-inflammatory, depending on whether they act on innate or adaptive immune cells. Taken together, our studies indicate that IL-13 production is more widespread than previously appreciated and that blocking this cytokine may have therapeutic benefits even in settings where traditional IL-4-driven Th2-type responses are not evident.

Original languageEnglish (US)
Pages (from-to)2322-2328
Number of pages7
JournalEuropean Journal of Immunology
Volume42
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • Adaptative response
  • IL-13
  • Th1
  • Th17
  • Th2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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